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ProteomicsProteome data for unbiased curvature-gradient proteomics reveals anti-curvature sensors
The results contain measurements of protein interacting with membranes of three different curvatures (positive, negative, and zero curvature).
ORGANISM(S): Homo Sapiens (human) 
2026-09-10 | PXD078093 | JPOST Repository
ProteomicsThe membrane curvature-inducing REEP1-4 proteins generate an ER-derived vesicular compartment
The endoplasmic reticulum (ER) is shaped by abundant membrane curvature-generating proteins that include the REEP family member REEP5. The REEP1 subfamily, consisting of REEP1-4 in mammals, is less abundant and lacks a N-terminal region. Mutations in REEP1 and REEP2 cause Hereditary Spastic Parapleg...
ORGANISM(S): Homo sapiens (Human) 
2025-01-18 | PXD055950 | Pride
Reep5 Reep1 Endoplasmic reticulum Membrane curvature Tubules Vesicles Hereditary spastic paraplegia 
GenomicsActive and Passive Mechanical Deficits Precede Spinal Curvature in a Zebrafish Model of Idiopathic Scoliosis
Active and Passive Mechanical Deficits Precede Spinal Curvature in a Zebrafish Model of Idiopathic Scoliosis
PRJNA1475277 | ENA
GenomicsA direct link between Prss53, hair curvature, and skeletal dysplasia
A direct link between Prss53, hair curvature, and skeletal dysplasia
PRJNA593251 | ENA
TranscriptomicsActive and Passive Mechanical Deficits Precede Spinal Curvature in a Zebrafish Model of Idiopathic Scoliosis
Idiopathic scoliosis is a common spinal disorder characterized by progressive three-dimensional curvature of unknown cause. Although biomechanical imbalance has long been proposed to contribute to scoliosis, the early physiological states that precede curvature onset remain poorly understood. Here, ...
ORGANISM(S): Danio rerio 
2026-06-05 | GSE334452 | GEO
TranscriptomicsRegulation of corneal stromal cell behavior by modulating curvature using a hydraulically-controlled organ chip array
Cornea exhibits distinct curvature-dependent mechanical environments that influence stromal cell phenotype and extracellular matrix remodeling. In this study, we employed a hydraulically-controlled cornea-on-a-chip platform to systematically vary curvature and examine transcriptional and phenotypic ...
ORGANISM(S): Homo sapiens 
2025-09-30 | GSE308374 | GEO
ProteomicsCore-dependent sheath architecture dictates Leptospira endoflagellar curvature
Spirochete bacteria include some of the most invasive human pathogens, causing diseases such as syphilis, Lyme disease, and leptospirosis that collectively affect millions of people annually. Their unique ability to penetrate tissues and cross biological barriers depends on periplasmic flagellar fil...
ORGANISM(S): Leptospira biflexa 
2026-07-14 | PXD073467 | Pride
Structural biology Xl-ms Leptospira endoflagellum 
ProteomicsA conserved membrane curvature-generating protein is crucial for autophagosome formation in fission yeast
Organelles are shaped by curvature-generating proteins, which include the reticulons and REEPs that are involved in forming the endoplasmic reticulum (ER). A conserved REEP subfamily differs from the ER-shaping REEPs in abundance and membrane topology and has unidentified functions. Here, we show th...
ORGANISM(S): Schizosaccharomyces pombe 927 
2023-08-06 | PXD043260 | Pride
Reep1 Autophagy Fission yeast 
GenomicsThe SBP transcription factor SPL10 regulates leaf curvature by promoting REVOLUTA transcription in plants
The SBP transcription factor SPL10 regulates leaf curvature by promoting REVOLUTA transcription in plants
PRJNA1052585 | ENA
ProteomicsCaspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation
The non-canonical inflammasome, consisting of caspase-4 in humans, initiates pyroptosis upon detecting cytosolic lipopolysaccharide (LPS) from Gram-negative bacteria. For its activation, caspase-4 binds the hydrophobic, membrane-embedded lipid A moiety of LPS, but how it accesses lipid A remains unk...
ORGANISM(S): Homo sapiens (Human) 
2026-03-10 | PXD070731 | Pride
Caspase-4 Immunology Lipopolysaccharide sensing Host-pathogen interaction gbp1 Membrane curvature Inflammasomes 
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