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ProteomicsAnalysis of mouse lens morphological and proteomic abnormalities following depletion of the betaB3-crystallin
Crystallin proteins serve as both essential structural and protective components of the ocular lens required for its transparency and light refraction. The mouse lens crystallin proteome is represented by alphaA-, alphaB-, betaA1-, betaA2-, betaA3-, betaA4-, betaB1-, betaB2-, betaB3-, gammaA-, gamma...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-01 | PXD059220 | Pride
Cytoplasm Isobaric labeling Cataract Proteomes Betab3-crystallin Lens Quantitative proteomics 
ProteomicsProteome-transcriptome analysis and proteome remodeling in mouse lens epithelium and fibers
Epithelial cells and differentiated fiber cells represent distinct compartments in the ocular lens. While previous studies have revealed proteins that are preferentially expressed in epithelial vs. fiber cells, a comprehensive proteomics library comparing the molecular composition of epithelial vs. ...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-05 | PXD009639 | Pride
Transcriptome Mouse lens Mass spectrometry Differentiation Transcription factors Proteome Rna-seq 
GenomicsIdentification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during lens and forebrain development
The transcription factor Pax6 is comprised of the paired domain (PD) and homeodomain (HD). In the developing forebrain, Pax6 is expressed in ventricular zone precursor cells and in specific subpopulations of neurons; absence of Pax6 results in disrupted cell proliferation and cell fate specification...
ORGANISM(S): Mus musculus 
2015-07-09 | E-GEOD-66961 | biostudies-arrayexpress
TranscriptomicsFunctional dissection of the Paired domain of Pax6 – distinct roles of subdomains in neurogenesis and proliferation
The transcription factor Pax6 acts as a key developmental regulator in various organs. In the developing brain Pax6 regulates patterning, neurogenesis and proliferation, but how these diverse effects are mediated at the molecular level is not well understood. As Pax6 regulates forebrain development ...
ORGANISM(S): Mus musculus 
2013-03-19 | E-GEOD-35260 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse LE-AP-2a mutants vs. wild-type P0 littermate lenses to investigate cell autonomous roles for AP-2alpha in lens vesicle separation and maintenance of the lens epithelial cell phenotype.
This is a comparative microarray analysis of LE-AP-2a mutants vs. wild-type P0 littermate lenses. This analysis revealed differential gene expression of 415 mRNAs, including reduced expression of genes important for maintaining lens epithelial cell phenotype, such as E-cadherin. Experiment Overall D...
ORGANISM(S): Mus musculus 
2009-01-31 | E-GEOD-14536 | biostudies-arrayexpress
TranscriptomicsTranscription profiling timecourse of induced DACH1 expression in a human breast cancer cell line
The vertebrate homologues of Drosophila dachsund, DACH1 and DACH2, have been implicated as important regulatory genes in development. DACH1 plays a role in retinal and pituitary precursor cell proliferation and DACH2 plays a specific role in myogenesis. DACH proteins contain a domain (DS-domain) tha...
ORGANISM(S): Homo sapiens 
2007-07-19 | E-GEOD-685 | biostudies-arrayexpress
TranscriptomicsChromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and their denucleation [lens tissue]
Genome-wide approach to identify the cell-autonomous role of Brg1 in lens fiber cell terminal differentiation. To examine roles of Brg1 in mouse lens development, a dnBrg1 transgenic construct was expressed using the lens-specific alphaA-crystallin promoter in postmitotic lens fiber cells. Morpholog...
ORGANISM(S): Mus musculus 
2011-01-01 | E-GEOD-22322 | biostudies-arrayexpress
TranscriptomicsHSF4 microarray gene expression analysis in the newborn mouse lens.
Differential expression of HSF4 in null newborn mouse and wildtype lenses was examined to identify putative downstream targets of HSF4. To examine roles of Brg1 in mouse lens development, a dnBrg1 transgenic construct was expressed using the lens-specific aA-crystallin promoter in postmitotic lens f...
ORGANISM(S): Mus musculus 
2010-12-01 | E-GEOD-22362 | biostudies-arrayexpress
TranscriptomicsIdentification and characterization of FGF2-dependent mRNA:microRNA networks during lens fiber cell differentiation
Background: FGF signaling controls numerous processes during cell lineage specification, organogenesis and terminal differentiation. In lens, FGF signaling was implicated as the key pathway that controls lens fiber cell differentiation, but little is known about its full range and spectrum of regula...
ORGANISM(S): Rattus norvegicus 
2013-09-06 | E-GEOD-50604 | biostudies-arrayexpress
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