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TranscriptomicsCyld CGH
In order to identify the function of the tumor suppressor CYLD in liver, we generate a liver specific disruption of this gene in mouse (liver specific CYLD KO mice). In our analysis it was revealed that these mice initially develop fibrosis and finally they develop spontaneous liver cancer after 1 y...
ORGANISM(S): mus_musculus 
2011-12-21 | E-MTAB-905 | biostudies-arrayexpress
ProteomicsRegulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
Non-degradative ubiquitin chains and phosphorylation events govern signaling responses by innate immune receptors. The deubiquitinase CYLD in complex with SPATA2 is recruited to receptor signaling complexes by the ubiquitin ligase LUBAC and regulates Met1- and Lys63-linked polyubiquitin and receptor...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD026791 | Pride
Cyld phosphorylation and ub-binding 
ProteomicsEGF-dependent ubiquitinome, phosphorylation and interactome analysis in control and CYLD-deficient cells
The goal of the present project was to investigate the EGF-dependent ubiquitination changes occurring in HeLa cells upon a CYLD deficiency. We applied SILAC-based quantitative mass spectrometry proteomics together with genetic engineering and biochemical approaches, in order to enrich the ubiquitina...
ORGANISM(S): Homo sapiens (Human) 
2017-06-05 | PXD003423 | Pride
Ubiquitination Egf Cyld 
TranscriptomicsTranscription profiling by array of human CYLD defective skin tumours and perilesional skin
Comparison of transcriptomes between CYLD defective skin tumours and perilesional skin
ORGANISM(S): Homo sapiens 
2011-08-16 | E-MTAB-352 | biostudies-arrayexpress
ProteomicsEGF-dependent ubiquitinome, phosphorylation and interactome analysis in control and CYLD-deficient cells
Cylindromatosis tumor suppressor protein (CYLD) is deubiquitinase, best known as an essential negative regulator of the NFkB pathway. Previous studies have suggested an involvement of CYLD in epidermal growth factor (EGF)-dependent signal transduction as well, as it was found enriched within the tyr...
ORGANISM(S): Homo sapiens (Human) 
2017-06-05 | PXD006390 | Pride
Cyld Prm Hela Phosphorylation Egfr Ubiquitin 
ProteomicsMouse heart proteomic analysis of CYLD-binding proteins
The peptide sequences identified by mass spectrometry in the proteins immunoprecipitated from the mouse ventricular lysate with the anti-CYLD antibody.
ORGANISM(S): Mus musculus (Mouse) 
2023-01-16 | PXD038360 | Pride
Mouse Heart 
TranscriptomicsThe Notch/Hes1 pathway sustains NF-M-NM-:B activation through CYLD repression in T cell leukemia
The NF-M-NM-:B pathway is a critical regulator of the immune system and has been implicated in cellular transformation and tumorigenesis. NF-M-NM-:B response is regulated by the activation state of the IM-NM-:B kinase (IKK) complex and triggered by a wide spectrum of stimuli. We previously reported ...
ORGANISM(S): Homo sapiens 
2011-05-07 | E-GEOD-20667 | biostudies-arrayexpress
ProteomicsEffect of insulin receptor knockdown on the proteome and secretome of CYLD cutaneous syndrome primary keratinocytes
CYLD cutaneous syndrome (CCS) is a rare genetic disorder characterized by multiple skin appendage tumors. This study investigated the impact of insulin receptor (INSR) knockdown on the cellular proteome and secretome of CCS primary keratinocytes. Three biological replicates each of control and INSR ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-28 | PXD071326 | Pride
Keratinocytes insr cyld 
ProteomicsTargeting non-canonical NF-κB signalling in CYLD cutaneous syndrome by selective inhibition of IκB kinase alpha
Proteome of CD45- sorted healthy skin (C1-C5) and CD45-/CD200+ CYLD cutaneous syndrome tumour samples (T1-T5).
ORGANISM(S): Homo sapiens (Human) 
2026-05-13 | PXD053466 | Pride
Cyld Skin Human Nf-kb 
TranscriptomicsCyldko
Effect of Cyld inactivation in liver. The Cyld gene was conditionally inactivated specifically in the liver by crossing mice carrying floxed exon 9 allele of Cyld with Alfp-Cre transgenic mice. Liver RNAs from Cyld lox/lox-AlfpCre mice were compared with RNAs prepared from the livers of wild type li...
ORGANISM(S): Mus musculus 
2012-02-01 | E-MEXP-3478 | biostudies-arrayexpress
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