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ProteomicsTRP14 is the rate limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation.
Identification of cysteinylated proteins in parental HEK cells and TRP14 knockdown HEK cells.
ORGANISM(S): Homo sapiens (Human) 
2024-05-10 | PXD050210 | Pride
Cysteinylated proteins 
UnknownCysteinylated protein as reactive disulfide: an alternative route to affinity labeling.
Not available
S-EPMC2443407 | biostudies-literature
ProteomicsCysteinylation of peroxiredoxin 2 upon incubation with BODIPY® FL L-Cystine
It has remained unknown how cells reduce cystine taken up from the extracellular space, which is a required step for further utilization of cysteine in key processes such as protein or glutathione synthesis. Here we show that the thioredoxin-related protein of 14 kDa (TRP14, encoded by TXNDC17) is t...
ORGANISM(S): Homo sapiens (Human) 
2024-05-10 | PXD050368 | Pride
Cysteinylated proteins 
ProteomicsTRP14 is the rate limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation. 42 proteins showed higher cysteinylation levels in TRP14 knockdown cells compared to wild-type cells upon biotinylated cysteine incubation and subsequent streptavidin pulldown. Figure 2C.
It has remained unknown how cells reduce cystine taken up from the extracellular space, which is a required step for further utilization of cysteine in key processes such as protein or glutathione synthesis. Here we show that the thioredoxin-related protein of 14 kDa (TRP14, encoded by TXNDC17) is t...
ORGANISM(S): Homo sapiens (Human) 
2024-06-05 | PXD038965 | Pride
Thioredoxin Pancreatitis Cysteinylation Bodipy 
ProteomicsCharacterization of the HLA class I Ligandome from Extracellular vesicles
Extracellular vesicles have shown promise in the field of anti-tumor vaccines. EVs are antigen-presenting entities capable of eliciting potent T-cell responses and have therefore being explored as cell-free based peptide vaccine vectors. However, whether the EV ligandome sufficiently resembles the c...
ORGANISM(S): Homo sapiens (Human) 
2021-07-05 | PXD021177 | Pride
Ev vaccines Extracellular vesicles Immunopeptidomics Ligandome Hla-i 
ProteomicsProteomic analysis of acute pancreatitis in TRP14-KO miceProteomic analysis of acute pancreatitis in TRP14-KO mice
We have studied pancreas samples in pancreas from a mouse model of acute pancreatitis, comparing wild-type animals and TRP14 KO animals. Samples are extracted with N-ethylmaleimide to block reduced cysteines, and no reducing agent is used, with a search including cysteinylated peptides. Acute pancr...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-15 | PXD050765 | Pride
Mouse model Cysteine Disulfide exchange Pancreatitis Biological redox systems Oxidative stress 
UnknownTRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation.
Not available
S-EPMC11217419 | biostudies-literature
UnknownPolyreactive anti-DNA monoclonal antibodies and a derived peptide as vectors for the intracytoplasmic and intranuclear translocation of macromolecules.
Not available
S-EPMC20424 | biostudies-literature
UnknownThe Regulatory Mechanism of Transthyretin Irreversible Aggregation through Liquid-to-Solid Phase Transition.
Not available
S-EPMC9960511 | biostudies-literature
UnknownRedox regulation in Bacillus subtilis: The bacilliredoxins BrxA(YphP) and BrxB(YqiW) function in de-bacillithiolation of S-bacillithiolated OhrR and MetE.
Not available
S-EPMC4076974 | biostudies-literature
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