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ProteomicsTemperature induced change of the HLA ligandome
Temperature induced change of the HLA ligandome and proteome in B-cells
ORGANISM(S): Homo sapiens (Human) 
2021-05-07 | PXD022930 | Pride
Hla class ii ligandome Hla class i ligandome Immunopeptidome Proteome Lc-ms/ms 
ProteomicsSampling from proteome to HLA-DR ligandome
Comprehensive analysis of the complex nature of the Human Leukocyte Antigen (HLA) class II ligandome is of utmost importance to understand the basis for CD4+ T cell mediated immunity and tolerance. Here, we implemented important improvements in the analysis of the repertoire of HLA-DR-presented pept...
ORGANISM(S): Homo sapiens (Human) 
2016-01-25 | PXD002951 | Pride
Ethcd Hcd Ligandome Hla class ii Etd Mhc class ii 
ProteomicsSampling from proteome to HLA-DR ligandome
Comprehensive analysis of the complex nature of the Human Leukocyte Antigen (HLA) class II ligandome is of utmost importance to understand the basis for CD4+ T cell mediated immunity and tolerance. Here, we implemented important improvements in the analysis of the repertoire of HLA-DR-presented pept...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-08-24 | MSV000082848 | MassIVE
ProteomicsTumour-associated antigenic peptides are present in the HLA class I ligandome of cancer cell line derived extracellular vesicles.
The recent success of monoclonal antibody checkpoint inhibitor therapies that enhance the ability of CD8+ T cells to detect cancer-related antigenic peptides has refocused the need to fully understand the repertoire of peptides being presented to the immune system. Whilst the peptide ligandome prese...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD025345 | Pride
Cancer Extracellular vesicles T-cell epitopes Taa Hla class i ligandome Evs Tumour. Tumour-associated antigens 
ProteomicsEstimating the Contribution of Proteasomal Spliced Peptides to the HLA-I Ligandome
Spliced peptides are short protein fragments spliced together in the proteasome by peptide bond formation. True estimation of the contribution of proteasome-spliced peptides (PSPs) to the global Human Leukocyte Antigen (HLA) ligandome is critical. A recent study suggested that PSPs contribute up to ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-11-13 | MSV000086452 | MassIVE
UnknownMultiplexed Pan Soluble Ligandome Assaying via OASIS.
Not available
S-EPMC12767521 | biostudies-literature
ProteomicsPre-fractionation extends, but creates a bias in the detectable HLA class Ι ligandome
HLA class Ι molecules on the cell surface enable CD8+ T lymphocytes to recognize cellular alterations in the form of antigens, including mutations, protein copy number alterations, aberrant post-translational modifications or pathogen proteins. At any given moment, tens of thousands of different sel...
ORGANISM(S): Homo sapiens (Human) 
2019-02-25 | PXD011257 | Pride
Hla class ι ligandome  hla class ι peptide ligands  high ph reversed phase  strong cation exchange  pre-fractionation 
UnknownThe human leukocyte antigen-presented ligandome of B lymphocytes.
Not available
S-EPMC3708169 | biostudies-literature
GenomicsMAETi enables high resolution MHC-I ligandome profiling from 10,000 cells and FACS sorted cell populations
MAETi enables high resolution MHC-I ligandome profiling
PRJEB109970 | ENA
ProteomicsZapnometinib treatment and influenza A virus infection induce alteration on the HLA class I ligandome of human lung adenocarcinoma cells
Targeting cellular factors is considered a promising approach to combat viral infection and overcome the resistance issue associated with direct-acting antiviral (DAA) drugs administration. In the context of drug repurposing strategies, we have previously explored the antiviral efficacy of the MEK i...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD041578 | Pride
Influenza a virus Ligandome analysis Mek inhibitors Zapnometinib Mhc-i Lc-ms/ms 
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