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MetabolomicsRibosomal mistranslation leads to silencing of the unfolded protein response and increased mitochondrial biogenesis

Translation fidelity is the limiting factor in the accuracy of gene expression. With an estimated frequency of 10-4, errors in mRNA decoding occur in a mostly stochastic manner. Little is known about the response of higher eukaryotes to chronic loss of ribosomal accuracy as per an increase in the...

2019-09-17 | MTBLS106 | MetaboLights
ProteomicsCytosolic protein Vms1 links ribosome quality control to mitochondrial and cellular homeostasis
Eukaryotic cells have evolved extensive protein quality control mechanisms to remove faulty translation products. Here we show that yeast cells continually produce faulty mitochondrial polypeptides that stall on the ribosome during translation but are imported into the mitochondria. The cytosolic pr...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-10-27 | PXD007800 | Pride
Mitochondria Rqc Ltn1 Vms1 
ProteomicsDeubiquitinase activity is required for the degradation of misfolded cytosolic proteins upon heat-stress
Elimination of misfolded proteins is crucial for proteostasis and to prevent proteinopathies. Nedd4/Rsp5 emerged as a major E3 ligase involved in multiple quality control pathways that target misfolded plasma membrane proteins, aggregated polypeptides, and cytosolic heat-induced misfolded proteins f...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-03-01 | PXD004747 | Pride
Deubiquitinase Cytosolic protein quality control Heat stress 
ProteomicsProtein quality control by MARCH6/TRC8
Forward genetic screens in human cells we find that the proteasome-mediated degradation of the soluble misfolded reporter, mCherry-CL1, involves two ER-resident E3 ligases, MARCH6 and TRC8. To identify a more physiological correlate we used quantitative mass spectrometry and found that TRC8 and MARC...
ORGANISM(S): Homo sapiens (Human) 
2018-04-18 | PXD008955 | Pride
Erad March6 Intramembrane proteolysis Trc8 Protein quality control 
UnknownCytosolic Quality Control of Mitochondrial Protein Precursors-The Early Stages of the Organelle Biogenesis.
Not available
S-EPMC8745001 | biostudies-literature
ProteomicsRsp5/Nedd4 is the major ubiquitin ligase that targets cytosolic misfolded proteins upon heat-stress
The heat-shock response is a complex cellular program that induces major changes in protein translation, folding and degradation to alleviate toxicity caused by protein misfolding. While heat-shock has been widely used to study proteostasis, it remained unclear how misfolded proteins are targeted fo...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2016-07-06 | PXD001214 | Pride
Rsp5 Heat-shock Cytosolic protein quality control 
UnknownHsp40/70/110 chaperones adapt nuclear protein quality control to serve cytosolic clients.
Not available
S-EPMC5987712 | biostudies-literature
UnknownThe degradation-promoting roles of deubiquitinases Ubp6 and Ubp3 in cytosolic and ER protein quality control.
Not available
S-EPMC7219781 | biostudies-literature
UnknownDegradation Signals for Ubiquitin-Proteasome Dependent Cytosolic Protein Quality Control (CytoQC) in Yeast.
Not available
S-EPMC4938640 | biostudies-literature
UnknownCytosolic protein quality control machinery: Interactions of Hsp70 with a network of co-chaperones and substrates.
Not available
S-EPMC8243209 | biostudies-literature
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