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ProteomicsIdentification of a novel class of cytotoxic granules as origin of supramolecular attack particles in T lymphocytes
Cytotoxic T lymphocytes (CTL) kill malignant and infected cells via cytotoxic proteins such as granzyme B (GzmB) that are released into the immunological synapse in the form of ~110 nm supramolecular attack particles (SMAPs). However, it is not known where SMAPs are stored in the cell and how they a...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-04 | PXD025055 | Pride
Exocytosis Proteomics Snare proteins Immunological synapse Cytotoxic granules Single core granules Supramolecular attack particles Total internal reflection fluorescence microscopy Correlative light and electron microscopy Multi core granules 
UnknownHDAC6 regulates the dynamics of lytic granules in cytotoxic T lymphocytes.
Not available
S-EPMC5023047 | biostudies-literature
UnknownIdentification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes.
Not available
S-EPMC8873490 | biostudies-literature
UnknownDistinct profiles of cytotoxic granules in memory CD8 T cells correlate with function, differentiation stage, and antigen exposure.
Not available
S-EPMC2655574 | biostudies-literature
UnknownSyntaxin 11 marks a distinct intracellular compartment recruited to the immunological synapse of NK cells to colocalize with cytotoxic granules.
Not available
S-EPMC3823099 | biostudies-literature
UnknownBehavior and Properties of Mature Lytic Granules at the Immunological Synapse of Human Cytotoxic T Lymphocytes.
Not available
S-EPMC4546685 | biostudies-literature
ProteomicsT-cell derived exosomes released from Multi-Core Granules exhibit potent caspase 3 mediated tumor suppressive activity
Small extracellular vesicles (sEV) derived from cytotoxic T lymphocytes (CTLs) are emerging as potential mediators of antitumor immunity, yet their subcellular origins and functional properties remain incompletely defined. In this study, we investigated the intracellular routes and cytotoxic potenti...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD064012 | Pride
Tetraspanins 10x-expansion Munc13-4 Extracellular vesicles Primary cells Cd8+ t-cells Immunological synapse Multivesicular bodies 
UnknownA signaling network stimulated by β2 integrin promotes the polarization of lytic granules in cytotoxic cells.
Not available
S-EPMC4205566 | biostudies-literature
ProteomicsComparative analysis of intra- and extracellular vesicles from cytotoxic CD8+ αβ T cells and γδ T cells
Although belonging to different branches of the immune system, cytotoxic CD8+ αβ T cells and γδ T cells utilize common cytolytic effectors including FasL, granzymes, perforin and granulysin. The effector proteins are stored in different subsets of lysosome-related effector vesicles (LREVs) and relea...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055377 | Pride
Exosomes Lysosome-related effector vesicles (lrevs) Cd8+ t cells Αβ t cells Cytotoxic granules Cytotoxic effector proteins Γδ t cells Cytotoxic t cells Proteomic profiling Extracellular vesicles (evs) 
ProteomicsT-cell derived exosomes released from Multi-Core Granules exhibit potent caspase 3 mediated tumor suppressive activity ( Part II)
Small extracellular vesicles (sEV) derived from cytotoxic T lymphocytes (CTLs) are emerging as potential mediators of antitumor immunity, yet their subcellular origins and functional properties remain incompletely defined. In this study, we investigated the intracellular routes and cytotoxic potenti...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD070419 | Pride
Tetraspanins 10x-expansion Munc13-4 Extracellular vesicles Primary cells Cd8+ t-cells Immunological synapse Multivesicular bodies 
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