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ProteomicsAnalysis of in vivo protein N-terminal acetylation of yeast GPM3 and its mutants
Multiple experiments were performed to study the level of in vivo protein N-terminal acetylation on GPM3 and its variants in yeast.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-10-16 | PXD064510 | Pride
Deuterium D6-acetic anhydride Yeast N-terminal acetylation Gpm3 
ProteomicsComparison of in-gel digestion methods for histone PTM analysis
In order to optimize the histone digestion procedure for low-abundance clinical samples, we compared different in-gel digestion protocols. Histones are usually digested in-gel using “Arg-C-like” strategies, which involve chemical acylation of lysines followed by trypsin digestion (17). Acylated lysi...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD024745 | Pride
Epigenetics Histone post-translationa modification 
UnknownHeparin stability by determining unsubstituted amino groups using hydrophilic interaction chromatography mass spectrometry.
Not available
S-EPMC4119833 | biostudies-literature
UnknownSite-specific quantification of lysine acetylation in the N-terminal tail of histone H4 using a double-labelling, targeted UHPLC MS/MS approach.
Not available
S-EPMC4837199 | biostudies-literature
ProteomicsYeast N-terminome SILAC - Formyl-methionine as an N-degron of a eukaryotic N-end rule pathway
Discerning yeast N-termionome with SILAC method. To analyze qualitative and quantitative analysis of N-formyl-methionine when introducing environmental stress.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-11-12 | PXD010780 | Pride
N-terminome Yeast Silac Formyl 
ProteomicsGlobal and specific responses of the histone acetylome to systematic perturbation
Regulation of histone acetylation is fundamental to the utilisation of eukaryotic genomes in chromatin. Aberrant acetylation contributes to disease and can be clinically combated by inhibiting the responsible enzymes. Our knowledge of the histone acetylation system is patchy because we so far lacked...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2015-01-09 | PXD001394 | Pride
Lc-msms Histone acetylome Drosophila 
ProteomicsLinking acetyl-CoA labelling and histone acetylation dynamics for accurate determination of acetylation rates via ordinary differential equations
To study complex biological systems, multi-omics methods have become an important tool. They integrate data from multiple biological layers, such as the metabolome and the proteome, to gain better insights of the processes happening. However, challenges remain both in sample preparation for measurem...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051487 | Pride
Human Lc-msms Acetylcoa Ptm Histone Acetylation Hek93t 
ProteomicsGcn5 and Esa1 function as histone crotonyltransferases to regulate crotonylation-dependent transcription
Histone post-translational modifications (PTMs) are critical for processes such as transcription. The more notable among these are the non-acetyl histone lysine acylation modifications such as crotonylation, butyrylation and succinylation. However, the biological relevance of these PTMs is not fully...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) Xenopus laevis (African clawed frog) 
2019-11-06 | PXD015488 | Pride
Gcn5-ada2-ada3 (ada) complex Histone modification Crotonylation Gene transcription Epigenetics Esa1- yng2-epl1 (piccolo nua4) complex 
ProteomicsChromID identifies the protein interactome at chromatin marks
Chromatin modifications instruct genome function through spatiotemporal recruitment of regulatory factors to the genome. However, how these modifications define the proteome composition at distinct chromatin states remains to be fully characterized. Here, we made use of natural protein domains as mo...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-30 | PXD017235 | Pride
Chromatin Systems biology Chromatin proteomics Epigenetics Synthetic biology 
ProteomicsHistone Modification Analysis of Oligodendroglioma and Astrocytoma Brain Cancer Samples
WHO classification for tumors of the central nervous system strongly endorses molecular tests for the precise diagnosis of diffuse gliomas. While alterations in the DNA methylation status of gliomas are already well documented and used in specialised clinical centers to distinguish between brain tum...
ORGANISM(S): Homo sapiens (Human) 
2020-01-17 | PXD015151 | Pride
Oligodendroglioma Histone modifications Brain cancer Astrocytoma Histone epi-proteome 
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