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ProteomicsAirway exosomes released during influenza virus infection serve as a key component of the antiviral innate immune response
Exosomes are extracellular vesicles secreted by cells that have an important biological function in intercellular communication by transferring biologically active proteins, lipids, and RNAs to neighbouring or distant cells. While a role for exosomes in antimicrobial defence has recently emerged, cu...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-03 | PXD018389 | Pride
Influenza Exosomes Mucosal immunity Antiviral activity Airway inflammation 
ProteomicsActivin A and NK cell function
Natural killer (NK) cells are innate lymphocytes that play a major role in immunosurveillance against tumor initiation and metastasis spread. Signals and checkpoints that regulate NK cell fitness and function in the tumor microenvironment are not well defined. Transforming grow factor (TGF)- is a re...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-06 | PXD011672 | Pride
Activin signaling Qtof Label-free proteomics Tgf-b signaling 
ProteomicsSperm-specific proteins and cancer testis antigens exist outside the blood-testis barrier
Sperm develop in the seminiferous tubules of the testis from puberty, sequestered inside the blood-testis barrier to prevent their recognition as “non-self” by the immune system. It is widely assumed that proteins expressed specifically in sperm do not have direct access to the circulation or the im...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-04-01 | PXD014333 | Pride
Testicular interstitial fluid Cancer-testis antigens Germ cell proteins 
ProteomicsTGFB1 induced S100 family protein expression is associated with epithelial to mesenchymal transition states and poor survival in pancreatic cancer
Epithelial-mesenchymal transition (EMT) is a continuum that includes epithelial, partial EMT (P-EMT) and mesenchymal states, each of which are associated with cancer progression, invasive capabilities and ultimately metastasis. We have employed a lineage traced sporadic model of pancreatic cancer to...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-24 | PXD030992 | Pride
Pancreatic cancer Emt S100 
ProteomicsCIS deficiency intensifies GM-CSF signaling to polarize alternative activated macrophages
GM-CSF paradoxically possesses ability to differentiate both classically activated macrophages (MØs) with dominant proinflammatory function (M1-like MØs) and alternative activated MØs with strong immunosuppressive function (M2-like MØs). The intrinsic regulatory mechanism responsible for functional ...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-21 | PXD018390 | Pride
Cis Gm-csf Macrophage polarization Tumour immunity 
ProteomicsPINK1-TOM-TIM23 complex SDA XL-MS
3xFLAG-tagged human wild-type PINK1 was expressed and immunoprecipitated with anti-FLAG beads. Chemical cross-linking MS (XL-MS) analysis using SDA and UV exposure was performed followed by in solution trypsin digestion and MS analysis.
ORGANISM(S): Homo Sapiens (human) 
2025-05-29 | PXD058526 | JPOST Repository
ProteomicsCalmodulin and CHK2 kinase crosslinking
Recombinant proteins were mixed and then crosslinked either with DMTMM or by SDA and UV exposure. Complexes were resolved by SDS-PAGE, excised and tryptic peptides identified by MS.
ORGANISM(S): Homo Sapiens (human) 
2026-03-28 | PXD062332 | JPOST Repository
ProteomicsPfs230 and Pfs48/45 complex SDA XL-MS
Asexual P. falciparum parasite cultures were maintained, gametocytes harvested and pellets lysed prior to chromatography procedures including size exclusion. Chemical cross-linking MS (XL-MS) analysis using SDA and UV exposure was performed followed by SDS-PAGE, gel bands excised and subjected to tr...
ORGANISM(S): Plasmodium (plasmodium) 
2026-01-27 | PXD060341 | JPOST Repository
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