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TranscriptomicsmicroRNA-like off-target transcript regulation by siRNAs
siRNAs mediate sequence-specific gene silencing in cultured mammalian cells but also silence unintended transcripts. Many siRNA off-target transcripts match the guide-strand ‘‘seed region,’’ similar to the way microRNAs match their target sites. The extent to which this seed-matched, microRNA-like, ...
ORGANISM(S): Mus musculus 
2009-01-31 | E-GEOD-14073 | biostudies-arrayexpress
TranscriptomicsNovel Transcriptome Profiling Analyses Demonstrate that Selective PPARg Modulators Display Attenuated and Selective Gene Regulatory Activity in Comparison with PPARg Full Agonists
We conducted extensive transcriptome profiling studies to characterize 70 SPPARgMs and seven PPARg full agonists in 3T3-L1 adipocytes, and a subset of these ligands in adipose tissue of diabetic db/db mice. In both cases, the SPPARgMs generated attenuated gene regulatory responses, and their gene ex...
ORGANISM(S): Mus musculus 
2012-06-29 | E-GEOD-31222 | biostudies-arrayexpress
TranscriptomicsProfiling of Human Adipose Tissue and Effect of Sibutramine on Gene Expression
We analyzed the expression of 23,653 transcripts in the adipose tissue of 19 individuals treated with Sibutramine Keywords: sibutramine effect 157 adipose tissue samples from 19 individuals treated with sibutramin as well as placebo were profiled for gene expression.
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-10545 | biostudies-arrayexpress
TranscriptomicsmiR-122 as a Regulator of Mitochondrial Metabolic Gene Network in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide, reflecting the need for a better understanding of hepatocarcinogenesis. In this study, we examined the genome-wide expression profiles of both miRNAs and mRNAs from paired tumor and adjacent non-tumor tissues fro...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-22058 | biostudies-arrayexpress
TranscriptomicsTemporal pattern of skeletal muscle gene expression following endurance exercise in Alaskan sled dogs
Background: Muscle responses to exercise are complex, and potentially include acute responses to exercise-induced injury as well as longer-term adaptive training responses. Using Alaskan sled dogs as an experimental model, changes in muscle gene expression were analyzed to better understand the tem...
ORGANISM(S): Canis lupus familiaris 
2010-05-16 | E-GEOD-15117 | biostudies-arrayexpress
TranscriptomicsDifferential expression of 24,426 human alternative splicing events and predicted cis-regulation in 48 tissues
Alternative pre-messenger RNA splicing impacts development, physiology, and disease, but its regulation in humans is not well understood, partially due to the limited scale to which the expression of specific splicing events has been measured. We generated the first genome-scale expression compendi...
ORGANISM(S): Homo sapiens 
2008-08-15 | E-GEOD-11863 | biostudies-arrayexpress
TranscriptomicsMicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression.
microRNAs in the miR-106b family are overexpressed in multiple tumor types and are correlated with the expression of genes that regulate the cell cycle. Consistent with these observations, miR-106b family gain of function promotes cell cycle progression, whereas loss of function reverses this phenot...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-14831 | biostudies-arrayexpress
TranscriptomicsGene expression changes associated with progression and response in chronic myeloid leukemia
Chronic myeloid leukemia (CML) is a hematopoetic stem cell disease with distinct biological and clinical features. The biological foundation of the stereotypical progression from chronic phase through accelerated phase to blast crisis is poorly understood. We used DNA microarrays to compare gene exp...
ORGANISM(S): Homo sapiens 
2010-06-11 | E-GEOD-4170 | biostudies-arrayexpress
TranscriptomicsEMT is the dominant program in human colon cancer (Agilent)
mRNA profiles on 129 colorectal tumors 129 colorectal tumors profiled on Agilent array using pool of individual tumors as common reference
ORGANISM(S): Homo sapiens 
2011-04-25 | E-GEOD-28722 | biostudies-arrayexpress
TranscriptomicsT lymphocyte activation gene identification by coregulated expression on DNA microarrays
High-capacity methods for assessing gene function have become increasingly important because of the increasing number of newly identified genes emerging from large-scale genome sequencing and cDNA cloning efforts. We investigated the use of DNA microarrays to identify uncharacterized genes specifica...
ORGANISM(S): Homo sapiens 
2004-01-31 | E-GEOD-902 | biostudies-arrayexpress
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