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TranscriptomicsCell cycle positioning drives heterogeneity within the pluripotent stem cell compartment
Heterogeneity in pluripotent cells marks a metastable state where cells may drift between native and lineage-primed populations. While the role for these heterogeneities are unclear, they may reflect the dynamic equilibriums of signaling networks and have a direct effect on differentiation potentia...
ORGANISM(S): Homo sapiens 
2013-12-19 | E-GEOD-53481 | biostudies-arrayexpress
TranscriptomicsNucleosome positioning changes during human embryonic stem cell differentiation.
Nucleosomes are the basic unit of chromatin. Nucleosome positioning (NP) plays a key role in transcriptional regulation and other biological processes. To better understand NP we used MNase-seq to investigate changes that occur as human embryonic stem cells (hESCs) transition to nascent mesoderm and...
ORGANISM(S): Homo sapiens 
2016-05-16 | E-GEOD-45877 | biostudies-arrayexpress
TranscriptomicsCell cycle analysis of histone marks and 4C in human Fucci ESCs
Using the Fucci cell cycle indicator system in hESCs, we evaluated the patterns of bivalent histone marks and enhancer histone marks during the cell cycle by ChIP-seq. We further evaluated how the chromatin architecture changed during the cell cycle. We found that bivalent domains are cell cycle r...
ORGANISM(S): Homo sapiens 
2015-06-23 | E-GEOD-61176 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human hepatic cells derived from foreskin fibroblast cell line and from embryonic stem cells.
Reprogrammed somatic cells offer a valuable source of pluripotent cells that have the potential to differentiate into many cells types and provide a new tool for regenerative medicine. In the present study we differentiated induced pluripotent stem cells (iPS cells) into hepatic cells. We first show...
ORGANISM(S): Homo sapiens 
2009-08-07 | E-GEOD-14897 | biostudies-arrayexpress
ProteomicsProteomic analysis of castrate resistant prostate cancer cell lines
In this study the development of androgen independence in a cell model of disease was selected as a mirror of to the events at play in the development of Castrate Resistant Prostate Cancer in-vivo. LNCaP cells which are androgen dependent and androgen independent sublines; LNCaP-Abl and LNCaP-Abl-Ho...
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD000751 | Pride
Lc-msms Proteomics Cell lines Prostate cancer 
GenomicsPCGP Histone-NSD2_RNASeq - samples
DATA FILES FOR Histone-NSD2_RNASeq
EGAD00001000655 | EGA
TranscriptomicsDistinct classes of genes behave as either drivers or dependents of replication timing switches (Replication-Timing).
Duplication of the genome in mammalian cells occurs in a defined temporal order referred as its replication-timing program (RT). RT is regulated in units of 400-800 Kb referred as replication domains (RDs) and changes dynamically during development. Changes in RT are generally coordinated with trans...
ORGANISM(S): Homo sapiens 
2015-05-28 | E-GEOD-63428 | biostudies-arrayexpress
GenomicsPCGP_SJLGG_Array_dataset - samples
SJLGG Case samples using Gene Expression Array
EGAD00010000462 | EGA
GenomicsPCGP LGG - samples
DATA FILES FOR SJLGG
EGAD00001000161 | EGA
GenomicsPCGP LGG WGS 2ndBatch - samples
DATA FILES FOR SJLGG
EGAD00001000695 | EGA
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