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ProteomicsTemplate-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders
Small molecules that induce protein-protein interactions to exert proximity-driven pharmacology such as targeted protein degradation are a powerful class of therapeutics1-3. Molecular glues are of particular interest given their favorable size and chemical properties and represent the only clinicall...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD047141 | Pride
Dcaf16 Jq1 Molecular glue Degrader Bromodomain Template-assisted 
ProteomicsTemplate-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders
Small molecules that induce protein-protein interactions to exert proximity-driven pharmacology such as targeted protein degradation are a powerful class of therapeutics1-3. Molecular glues are of particular interest given their favorable size and chemical properties and represent the only clinicall...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD047137 | Pride
Dcaf16 Jq1 Molecular glue Degrader Bromodomain Template-assisted 
UnknownExploration of the tunability of BRD4 degradation by DCAF16 trans-labelling covalent glues.
Not available
S-EPMC11960843 | biostudies-literature
UnknownTemplate-assisted covalent modification underlies activity of covalent molecular glues.
Not available
S-EPMC11582070 | biostudies-literature
UnknownTemplate-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders.
Not available
S-EPMC9949066 | biostudies-literature
ProteomicsTemplate-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders
Small molecules that induce protein-protein interactions to exert proximity-driven pharmacology such as targeted protein degradation are a powerful class of therapeutics1-3. Molecular glues are of particular interest given their favorable size and chemical properties and represent the only clinicall...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD047138 | Pride
Dcaf16 Jq1 Molecular glue Degrader Bromodomain Template-assisted 
ProteomicsBiotinylated MMH2 pulldown LCMS
Here, we present structural and mechanistic studies that define a trans-labeling covalent molecular glue mechanism. We found that a novel series of BRD4 molecular glue degraders act by recruiting the CUL4-DCAF16 ligase to the second bromodomain of BRD4. To gain a deeper understanding into the potent...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051457 | Pride
Human Lc-msms Molecular glue 
UnknownDeciphering neutrophil dynamics in the focal lesion tumor microenvironment to overcome immunosuppression in multiple myeloma.
Not available
S-EPMC12824687 | biostudies-literature
UnknownDynamic Reprogramming of Stromal Pdgfra-expressing cells during WNT-Mediated Transformation of the Intestinal Epithelium.
Not available
S-EPMC11785226 | biostudies-literature
UnknownFrizzled5 controls murine intestinal epithelial cell plasticity through organization of chromatin accessibility.
Not available
S-EPMC11794035 | biostudies-literature
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