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TranscriptomicsOutcomes of Allogeneic Hematopoietic Cell Transplantation in Adults with fusions associated with Ph-like ALL
Allogenic hematopoietic cell transplantation (alloHCT) is a well-established curative modality for adults with high-risk ALL; yet large data describing alloHCT outcomes in Philadelphia (Ph)-like ALL is lacking. We retrospectively analyzed archived DNA samples from consecutive adults with B-cell Ph-n...
ORGANISM(S): Homo sapiens 
2022-08-01 | E-MTAB-11954 | biostudies-arrayexpress
ProteomicsMuscle stems cell LC-MS - Common and Distinctive Functions of the Hippo Effectors Taz and Yap in Skeletal Muscle Stem Cell Function
Abstract Hippo pathway downstream effectors Yap and Taz play key roles in cell proliferation and regeneration, regulating gene expression especially via interaction with Tead transcription factors. To investigate their role in skeletal muscle stem cells, we analysed Taz in vivo and ex vivo in compar...
ORGANISM(S): Mus musculus (Mouse) 
2017-06-13 | PXD005751 | Pride
Taz Muscle Yap 
MetabolomicsInterorganelle lipid flux revealed by enzymatic mass tagging in vivo
The distinct activities of cellular organelles are dependent on the proper function of their membranes. Coordinated membrane biogenesis of the different organelles necessitates interorganelle transport of lipids from their site of synthesis to their destination membranes. Several proteins and traffi...
2022-03-22 | MTBLS3415 | MetaboLights
TranscriptomicsRNA-Seq of mRNA derived from fourth larval stage larvae from C. elegans strain PE1328 treated for 16 hours at 20 degrees Celsius with 5-Ph-IAA compared to untreated controls
The objective of the experiment was to determine the impact of cap-adjacent 2'-O-ribose methylation on steady-state mRNA levels in a background lacking the decapping exonculease EOL-1. We depleted CMTR-1 protein, which is the main enzyme responsible for of cap-adjacent 2'-O-ribose methylation in C. ...
ORGANISM(S): Caenorhabditis elegans 
2026-03-05 | E-MTAB-16687 | biostudies-arrayexpress
TranscriptomicsChIP-chip by array of human K562, U937 and CD14+ cells to identify histone modifcations in ENCODE regions
Chromatin immunoprecipitation microarray (ChIP-chip) study using 3 human cell lines (K562, U937, CD14+); of 19 histone modifications across 1% of the human genome used in the pilot phase of the ENCODE project.
paper abstract: It has recently been shown that nucleosome distribution, histone modifi...
ORGANISM(S): Homo sapiens 
2010-12-29 | E-MTAB-334 | biostudies-arrayexpress
TranscriptomicsChIP-chip by array of human cells for whole genome profiling of 4 histone modifications
Whole genome profiling of 4 histone modifications (H3K27me1, H3K27me3,H3K36me1 and H3K36me3) using ChIP-on-chip. It has recently been shown that nucleosome distribution, histone modifications and RNA polymerase II (Pol II) occupancy show preferential association with exons ("exon-intron marking"), l...
ORGANISM(S): Homo sapiens 
2010-12-03 | E-MTAB-336 | biostudies-arrayexpress
ProteomicsDrought response in glacier-fed stream biofilms
Protein extracted from glacier-fed stream biofilms, before and after being exposed to a 24h drought (Val Ferret, Switzerland). Associated metagenomics and metatranscriptomics data are available under the NCBI Bioproject PRJNA1273015.
ORGANISM(S): biofilm metagenome aquatic metagenome 
2026-02-23 | PXD067889 | Pride
Biofilm Glacier-fed stream Drought 
no omics definedTranscription profiling of human Vg9/Vd2 T cells after 72h stimulation with HMB-PP in the presence of IL-2, IL-4, or IL-21
Hver2.1.1 microarrays containing ~15,000 genes were used to characterize the gene expression profiles of Vg9/Vd2 T cells upon 72h stimulation with HMB-PP in the presence of IL-2, IL-4, or IL-21.
ORGANISM(S): Homo sapiens 
2007-03-21 | E-MEXP-763 | biostudies-arrayexpress
MetabolomicsIAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function
The islet in type 2 diabetes (T2D) is characterized by amyloid deposits derived from islet amyloid polypeptide (IAPP), a protein co-expressed with insulin by β-cells. In common with amyloidogenic proteins implicated in neurodegeneration, human IAPP (hIAPP) forms membrane permeant toxic oligomers imp...
2020-04-17 | MTBLS951 | MetaboLights
TranscriptomicsChromatin immunoprecipitation of human erythroleukemia cell line K-562 with H3K4me2, H3K4me3, H3ac, H4ac, Histone H2B and Histone H3 antibodies using an ENCODE array
ENCODE ChIP-chip study using human myelogenous leukemia cell line K-562 and anti histone H3K4me2 (Abcam; ab7766); H3K4me3 (Abcam; ab8580); H3ac (Upstate; 06-599); H4ac (Upstate; 06-866); Histone H2B (Abcam: ab1790) and Histone H3 (Abcam: ab1791) antibodies. Each antibody experiment was conducted in ...
ORGANISM(S): Homo sapiens 
2006-09-01 | E-TABM-140 | biostudies-arrayexpress
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