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TranscriptomicsEffect of DBC1/CCAR2 knockout on global gene expression in SW480 cells
Deleted in breast cancer (DBC1; also known as CCAR2) is a coactivator for nuclear receptors (NRs) and other transcription factors as well as a negative regulator of epigenetic modifiers such as deacetylases SIRT1 and HDAC3. We performed genome-wide gene expression analysis in wild-type and DBC1 knoc...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-65841 | biostudies-arrayexpress
ProteomicsProteomic profile of deleted in breast cancer 1 protein-protein interactions
Deleted in breast cancer 1 (DBC1) has emerged as an important regulator of multiple cellular processes, ranging from gene expression to cell cycle progression. DBC1 has been linked to tumorigenesis both as an inhibitor of histone deacetylases (HDAC), HDAC3 and sirtuin 1 (SIRT1), and as a transcripti...
ORGANISM(S): Homo sapiens (Human) 
2015-12-17 | PXD002733 | Pride
Sirt Protein interactions Saint Hdac Affinity purification 
ProteomicsDBC1 regulates p53 stability via inhibition of CBP-dependent p53 polyubiquitination
The control of p53 protein stability is critical to its tumor suppressor functions. The CREB Binding Protein (CBP) transcriptional coactivator co-operates with MDM2 to maintain normally low physiologic p53 levels in cells via an exclusively cytoplasmic ‘E4’ polyubiquitination activity. Utilizing mas...
ORGANISM(S): Homo sapiens (Human) 
2019-11-13 | PXD012673 | Pride
Lc-msms Apoptosis Ubiquitin Cbp Dbc1 P53 
TranscriptomicsGene expression analysis of DBC1 KO B cells
DBC1 KO B cells were either unstimulated, activated with anti-IgM, anti-CD40 of LPS for 4 hours. Genes differentially expressed in DBC1 KO B cells were compared to WT B cells. RNA was collected from unstimulated for stimulated B cells, and gene expression between WT and DBC1 KO B cells were compared
ORGANISM(S): Mus musculus 
2014-09-04 | E-GEOD-61029 | biostudies-arrayexpress
TranscriptomicsEffect of DBC1/CCAR2 depletion on global gene expression in MDA-MB-231 cells
Deleted in breast cancer (DBC1; also known as CCAR2) is a coactivator for nuclear receptors (NRs) as well as a negative regulator of epigenetic modifiers such as deacetylases SIRT1 and HDAC3. We performed genome-wide gene expression analysis in control (shNS) and DBC1-depleted (shDBC1) MDA-MD-231 ce...
ORGANISM(S): Homo sapiens 
2015-01-31 | E-GEOD-54707 | biostudies-arrayexpress
GenomicsDBC1 is a positive regulator of enhancer epigenomic writers KMT2D and p300.
DBC1 is a positive regulator of enhancer epigenomic writers KMT2D and p300.
PRJNA836274 | ENA
GenomicsDBC1 is a positive regulator of enhancer epigenomic writers KMT2D and p300 [ChIP-Seq]
DBC1 is a positive regulator of enhancer epigenomic writers KMT2D and p300 [ChIP-Seq]
PRJNA743891 | ENA
GenomicsDBC1 is a positive regulator of enhancer epigenomic writers KMT2D and p300 [HCT116 ChIP-seq]
DBC1 is a positive regulator of enhancer epigenomic writers KMT2D and p300 [HCT116 ChIP-seq]
PRJNA831099 | ENA
TranscriptomicsGene expression analysis of DBC1 KO B cells
DBC1 KO B cells were either unstimulated, activated with anti-IgM, anti-CD40 of LPS for 4 hours. Genes differentially expressed in DBC1 KO B cells were compared to WT B cells.
ORGANISM(S): Mus musculus 
2014-09-04 | GSE61029 | GEO
ProteomicsIdentification of DBC1 as a regulator of mitosis and a link between LKB1 and AKT
Role of DBC1 in mitotic progression, AKT activation and tumorigenesis
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-04-19 | MSV000087239 | MassIVE
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