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We used HDX-MS to analyze which regions of the DDD complex are intrinsically ordered and disordered. Deuterium incorporation after 3 seconds at zero degrees celsius was compared to deuterium incoporation in a fully deuterated sample. We were able to determine which componants of the DDD complex have...
ORGANISM(S): Homo sapiens (Human) 
2025-03-10 | PXD057548 | Pride
The Deciphering Developmental Disorders (DDD) study is a research collaboration between the Wellcome Trust Sanger Institute, the NHS clinical genetics services and families across the UK and Ireland. The project aims to improve the diagnosis of children with developmental disorders by using high-res...
Genomics
The genomes of two Ddd+ actinobacteria
Ubiquitin modification regulates fundamental cellular processes by controlling protein stability and function. The ubiquitin ligase COP1, conserved from plants to humans, targets developmental transcription factors. COP1 can act on its own or be incorporated into CULLIN4–RING ligase (CRL4) complexes...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD071633 | Pride
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