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ProteomicsSINE RNAs trigger noncanonical NLRC4 inflammasome via DDX17
Short interspersed element (SINE) RNAs are upregulated by cellular stresses1 (heat shock, DNA damage and viral infection) and accumulate in human diseases (macular degeneration2, lupus3, and Alzheimer’s disease4). These transcripts activate inflammasomes5, a family of cytoplasmic multiprotein comple...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD016019 | Pride
Sine Ddx17 Amd Inflammasome 
TranscriptomicsRNA helicases DDX5 and DDX17 dynamically orchestrate transcription, microRNA and splicing programs in cell differentiation
RNA helicases DDX5 and DDX17 are members of a large family of highly conserved proteins involved in gene expression regulation, although their in vivo targets and activities in biological processes like cell differentiation, that requires reprogramming of gene expression programs at multiple levels,...
ORGANISM(S): Homo sapiens 
2014-05-06 | E-GEOD-57281 | biostudies-arrayexpress
ProteomicsDDX17 helicase promotes resolution of R-loop-mediated transcription-replication conflicts in human cells
R-loops are three-stranded nucleic acid structures composed of an RNA:DNA hybrid and displaced DNA strand. These structures can halt DNA replication when formed co- transcriptionally in the opposite orientation to replication fork progression. Recent studies have shown that replication forks stalled...
ORGANISM(S): Homo sapiens (Human) 
2022-11-02 | PXD034331 | Pride
Dna replication stress  r-loop  helicase  genomic instability  transcription 
GenomicsEffect of overexpression of DDX17(P82) on gene expression in LIM1215 cells
Effect of overexpression of DDX17(P82) on gene expression in LIM1215 cells
PRJNA1445907 | ENA
UnknownDDX17 promotes the growth and metastasis of lung adenocarcinoma.
Not available
S-EPMC9588018 | biostudies-literature
UnknownDTMUV upregulates DDX17 expression to facilitate viral replication.
Not available
S-EPMC12709809 | biostudies-literature
GenomicsTranscriptome analysis of neuroblastoma SH-SY5Y cells upon DDX17 helicase knock-down
Transcriptome analysis of neuroblastoma SH-SY5Y cells upon DDX17 helicase knock-down
PRJNA924795 | ENA
UnknownMonoallelic de novo variants in DDX17 cause a neurodevelopmental disorder.
Not available
S-EPMC11967813 | biostudies-literature
GenomicsDEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure
DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure
PRJNA660244 | ENA
UnknownHuman DDX17 Unwinds Rift Valley Fever Virus Non-Coding RNAs.
Not available
S-EPMC7793125 | biostudies-literature
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