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Targeting the histone methyltransferase DOT1L rewires CD8 T cells and enhances their intrinsic cytotoxic activity towards tumor cells

Insights into the epigenetic mechanisms of CD8 T cell differentiation are delivering novel opportunities for modulating fate decisions and immune responses. The histone methyltransferase DOT1L is emerging as central epigenetic regulator in immune cells. However, its cell-intrinsic role in CD8 T cell...

ORGANISM(S): Mus musculus (Mouse)

2025-11-10 | PXD057606 | Pride

CD4⁺ T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors.

Not available

S-EPMC10978876 | biostudies-literature

A novel unusual chromosome 11 abnormality: a homozygous somatic deletion of the entire WT1 gene within a heterozygous 11p13 deletion and UPD limited to 11p15 in a Wilms tumor and establishment of an immortalized cell line

We describe a stromal predominant Wilms tumor with a complex, tumor specific chromosome 11 aberration: a homozygous deletion of the entire WT1 gene within a heterozygous 11p13 deletion and an additional region of uniparental disomy (UPD) limited to 11p15.5-p15.2 including the IGF2 gene. The tumor ca...

ORGANISM(S): Homo sapiens

2016-06-01 | E-GEOD-71265 | biostudies-arrayexpress

Co-Expression of TIGIT and Helios Marks Immunosenescent CD8⁺ T Cells During Aging.

Not available

S-EPMC9148977 | biostudies-literature

Antigen-specific B cells reactivate an effective cytotoxic T cell response against phagocytosed Salmonella through cross-presentation.

Not available

S-EPMC2946406 | biostudies-literature

Histone methyltransferase DOT1L maintains cell state and restricts cytotoxic potential of CD8 T cells.

Not available

S-EPMC12700201 | biostudies-literature

CD4⁺ helper T cells endow cDC1 with cancer-impeding functions in the human tumor micro-environment.