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TranscriptomicsRocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor
Rocaglamide A (RocA) typifies a class of protein synthesis inhibitors that selectively kill aneuploid tumor cells and repress translation of specific mRNAs. RocA targets eukaryotic initiation factor 4A (eIF4A), an ATP-dependent DEAD-box RNA helicase; its mRNA selectivity is proposed to reflect highl...
ORGANISM(S): synthetic construct 
2016-06-15 | E-GEOD-79392 | biostudies-arrayexpress
GenomicsMediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA
CCCTC-binding factor (CTCF) is a DNA-binding protein that plays important roles in chromatin organization, though the mechanism by which CTCF carries out these functions is not fully understood. Recent studies show that CTCF recruits the cohesin complex to insulator sites and that cohesin is require...
ORGANISM(S): Homo sapiens 
2010-11-16 | E-GEOD-24126 | biostudies-arrayexpress
TranscriptomicsRNase R is associated in a functional complex with the RhpA DEAD-box RNA helicase in Helicobacter pylori
Ribonucleases (RNases) are central actors in post-transcriptional regulation, a major level of regulation of gene expression in all cells. This control plays an important role in the bacterial pathogen Helicobacter pylori, although only the function of RNase J was characterized so far. Here, we stud...
ORGANISM(S): Helicobacter pylori 
2021-06-19 | E-MTAB-10045 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of wild type and p72 knock-out mice embryos
To examine the effect of DEAD-box RNA helicase subunits on the primary miRNAs processing by Drosha complex, we made knockout mice of p72, DEAD-box RNA helicase, a component of Drosha complex. And we compare the miRNA expression profiles derived from whole mice embryo between wild-type and p72 KO mic...
ORGANISM(S): Mus musculus 
2007-04-12 | E-MEXP-1052 | biostudies-arrayexpress
ProteomicsUbiquitination of DEAD-box RNA helicase DDX3X by TRIM25
Tripartite motif protein 25 (TRIM25) is an E3 ligase that ubiquitinates multiple substrates within the RLR signalling cascade and plays both RING (really interesting new gene)-dependent and RING-independent roles in RIG-I-mediated IFN induction. We report that the PRY-SPRY domain of TRIM25 interacts...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD028122 | Pride
Ddx3x Trim25 Ubiquitin 
GenomicsThe DEAD-box RNA helicase Ded1 is a translation-elongation factor
The DEAD-box RNA helicase Ded1 is a translation-elongation factor
PRJNA951699 | ENA
TranscriptomicsRocaglamide A converts RNA helicase eIF4A into a sequence-specific translational repressor
Rocaglamide A (RocA) typifies a novel class of protein synthesis inhibitors that selectively kill aneuploid tumor cells and repress translation of specific mRNAs. RocA targets eukaryotic initiation factor 4A (eIF4A), the prototypical DEAD-box RNA helicase, and its mRNA selectivity is proposed to ref...
ORGANISM(S): synthetic construct 
2016-06-15 | E-GEOD-70211 | biostudies-arrayexpress
ProteomicsComparative analysis of the interactome of a homologue of the DEAD-box RNA helicase eIF4A and its mutant version (DQAD) from Trypanosoma brucei
eIF4A is a RNA helicase considered the prototype for the DEAD-box family and it is required in different events associated with the metabolism of RNAs, with the DEAD motif important to its ATPase and helicase activities. Previous studies have indicated that EIF4AI is the functional homolog working o...
ORGANISM(S): Trypanosoma brucei 
2025-05-26 | PXD049425 | Pride
Eif4f Translation initiation Eif4a Rna helicase 
TranscriptomicsGenome-wide identification of mis-spliced/intron-retained transcripts in Arabidopsis thaliana rcf1-1 mutant plants under normal growth conditions as determined by tiling array analysis.
Cold stress is one of the most severe environmental conditions which cause huge losses in crop production worldwide. We identified a DEAD box RNA helicase, RCF1 (Regulator of CBF gene expression 1) that controls pre-mRNA splicing of cold-stress-responsive genes including positive and negative regula...
ORGANISM(S): Arabidopsis thaliana 
2013-02-25 | E-GEOD-41377 | biostudies-arrayexpress
TranscriptomicsGenome-wide identification of mis-spliced/intron-retained transcripts in Arabidopsis thaliana rcf1-1 mutant plants under cold stress as determined by tiling array analysis.
Cold stress is one of the most severe environmental conditions which cause huge losses in crop production worldwide. We identified a DEAD box RNA helicase, RCF1 (Regulator of CBF gene expression 1) that controls pre-mRNA splicing of cold-stress-responsive genes including positive and negative regula...
ORGANISM(S): Arabidopsis thaliana 
2013-02-25 | E-GEOD-41378 | biostudies-arrayexpress
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