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ProteomicsIdentification of interactors of Arabidopsis VIN3 and VRN5 proteins in vernalized seedlings
The Arabidopsis VEL proteins VIN3 and VRN5 are accessory proteins of the Polycomb Repressive Complex 2 (PRC2). Their function is most well-understood in the epigenetic PRC2-mediated silencing of the floral repressor gene Flowering Locus C (FLC) during prolonged cold (vernalization). To identify prot...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-08-28 | PXD048844 | Pride
Prc2 Gene silencing Vernalization Epigenetics Polycomb Vel domain 
ProteomicsVRN1-associated proteins in Arabidopsis thaliana
The epigenetic silencing of the Arabidopsis floral repressor gene FLOWERING LOCUS C (FLC) is induced by a prolonged period of cold and promotes the developmental transition to flowering post-cold. FLC silencing requires the function of VRN1, a non-sequence-specific DNA binding protein. Here, we used...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-05-07 | PXD054597 | Pride
Arabidopsis Chromatin Epigenetic silencing Flowering 
Proteomics: Identification of interactors of Arabidopsis VIN3 wildtype and VIN3 chimeric mutant protein in vernalized seedlings
The Arabidopsis VEL proteins VIN3 and VRN5 are accessory proteins of the Polycomb Repressive Complex 2 (PRC2). Their function is most well-understood in the epigenetic PRC2-mediated silencing of the floral repressor gene Flowering Locus C (FLC) during prolonged cold (vernalization). To identify prot...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-08-28 | PXD064199 | Pride
Prc2 Gene silencing Vernalization Epigenetics Polycomb Vel domain 
ProteomicsVAL1 acts as an assembly platform co-ordinating co-transcriptional repression and chromatin 2 regulation at Arabidopsis FLC
• Polycomb (PcG) regulation is crucial for development across eukaryotes, but how PcG targets are specified is still incompletely understood. The slow timescale of cold-induced Polycomb Repressive Complex 2 silencing during vernalization at Arabidopsis thaliana FLOWERING LOCUS C (FLC) provides an ex...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-10-13 | PXD036548 | Pride
Asap Arabidopsis Vernalisation Polycomb Transcription factor Chromatin regulation Prc1 Epigenetics Gene silencing Orbitrap fusion 
ProteomicsA CPSF-like phosphatase module links transcription termination to chromatin silencing
Aiming to find the connection between RNA processing and chromatin remodelling, we found that a complex removing activating histone marks at FLC named FLD complex interacts with ARPF1, one of the homologs in Arabidopsis of the yeast Swd2. In this experiment, we used a FLAG-tagged version of the ARPF...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-05-13 | PXD049114 | Pride
Proteomics Rna-processing Swd2-like Chromatin Co-immunoprecipitatiion Cpsf 
ProteomicsVAL1 acts as an assembly platform co-ordinating co-transcriptional repression and chromatin regulation at Arabidopsis FLC
Polycomb (PcG) silencing is crucial for development, but how targets are specified remains incompletely understood. The cold-induced Polycomb Repressive Complex 2 (PRC2) silencing of Arabidopsis thaliana FLOWERING LOCUS C (FLC) provides an excellent system to elucidate PcG regulation. Association...
ORGANISM(S): Arabidopsis Thaliana 
2022-08-15 | PXD036057 |
TranscriptomicsCold-induced silencing mediated by long antisense FLC transcripts
Hight throughput techniques have revealed huge complexity in antisense RNAs in many organisms. We have explored the complexity of this class of transcripts and functional links to Polycomb silencing thought analysis of non-coding RNAs of Arabidopsis FLC. FLC is repressed and epigenetically silenced ...
ORGANISM(S): Arabidopsis thaliana 
2009-12-31 | E-GEOD-16977 | biostudies-arrayexpress
UnknownModular in vivo assembly of Arabidopsis FCA oligomers into condensates competent for RNA 3' processing
Not available
S-SCDT-10_1038-S44318-025-00394-4 | biostudies-other
UnknownThe effect of age on efficacy, safety and patient-centered outcomes with rucaparib: A post hoc exploratory analysis of ARIEL3, a phase 3, randomized, maintenance study in patients with recurrent ovarian carcinoma.
Not available
S-EPMC8450972 | biostudies-literature
UnknownTocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC8084355 | biostudies-literature
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