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ProteomicsThe equine granulocyte proteome: expression changes in autoimmune disease and after stimulation
We investigated the granulocyte proteome from healthy horses, horses with a spontaneous autoimmune disease (equine recurrent uveitis) and the reaction of granulocytes to different stimuli (IL8, PMA, LPS) on protein level. A total of 2032 proteins describing the whole granulocyte proteome were identi...
ORGANISM(S): Equus caballus (Horse) 
2020-01-15 | PXD013648 | Pride
Granulocyte Autoimmune disease Il8 
Proteomicsequine CD4+ T cells show changed membrane protein expression in autoimmune uveitis
Through this comparative proteomic study of equine CD4+ cells 376 membrane proteins could be identified. Several proteins showed changed abundance in horses affected by a spontaneous autoimmune disease (equine recurrent uveitis, ERU). Findings provide novel knowledge about changes in the CD4+ immune...
ORGANISM(S): Equus caballus (Horse) 
2017-01-09 | PXD005384 | Pride
Lc-msms mass spectrometry analysis Membrane proteins Cd4+ t cells Autoimmune uveitis Equine recurrent uveitis 
Proteomicsaltered bovine lymphocyte secretome after pokeweed mitogen stimulation
Vaccination with a new vaccine against bovine viral diarrhea (BVD) caused unwanted immune reactions through alloreactive antibody production in 5–10% of vaccinated cows. Transfer of these alloreactive antibodies via colostrum caused highly lethal (90%) bovine neonatal pancytopenia (BNP) in calves. D...
ORGANISM(S): Bos taurus (Bovine) 
2022-02-10 | PXD017892 | Pride
Immune system Polyclonal cell stimulation Ltq orbitrap xl. Bovine neonatal pancytopenia Vaccine Cow Deviant immune reactions 
ProteomicsCathepsin S in Mycobacterium avium subsp. paratuberculosis Infected Dairy Cows
In this study, samples of 16 dairy cows from a MAP infected farm were used. Serum, milk and fecal samples were collected. Categorizing these cows into two groups based on their MAP infection status different standard methods for detection MAP were applied. Healthy controls showed no positive results...
ORGANISM(S): Bos taurus (Bovine) 
2024-06-22 | PXD048042 | Pride
Preomics Serum Label-free mass spectrometry 
ProteomicsThe porcine granulocyte proteome: expression changes in a transgenic pig model for diabetes
As transgenic INSC94Y-pigs develop a stable diabetic phenotype we were able to study the influence of elevated blood glucose levels on primary immune cells in vivo. We investigated the neutrophil proteome and compared data of transgenic animals to a control group. A total of 2371 proteins describing...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2020-06-04 | PXD017274 | Pride
Differential proteomics Innate immune cell Neutrophil granulocyte Diabetes 
ProteomicsCD11d is a novel antigen on chicken PBMC
Using Immunoprecipitation (IP) and mass spectrometry analysis, we aimed at identifying the target of a self-made monoclonal antibody to an unknown molecule on the outer membranes of chicken peripheral blood derived mononuclear cells (PBMC).
ORGANISM(S): Gallus gallus (Chicken) 
2020-06-18 | PXD017248 | Pride
Pbmc Chicken Immunoprecipitation Cd11d 
ProteomicsChanges in bovine Lymphocyte proteome after stimulation with pokeweed mitogen
A new vaccine against bovine viral diarrhea (BVD) induced unwanted immune reactions with production of alloreactive antibodies in 5–10% of vaccinated cows. Transfer of these antibodies via colostrum caused bovine neonatal pancytopenia (BNP) in calves, with a lethality rate of 90%. The exact immunolo...
ORGANISM(S): Bos taurus (Bovine) 
2022-02-10 | PXD017350 | Pride
Pokeweed mitogen  polyclonal cell stimulation  immune reaction Cow 
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