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ProteomicsThe equine granulocyte proteome: expression changes in autoimmune disease and after stimulation
We investigated the granulocyte proteome from healthy horses, horses with a spontaneous autoimmune disease (equine recurrent uveitis) and the reaction of granulocytes to different stimuli (IL8, PMA, LPS) on protein level. A total of 2032 proteins describing the whole granulocyte proteome were identi...
ORGANISM(S): Equus caballus (Horse) 
2020-01-15 | PXD013648 | Pride
Granulocyte Autoimmune disease Il8 
TranscriptomicsTranscription profiling of human CD34+ stem/progenitor cell populations mobilized into the blood by granulocyte colony-stimulating factor
Mononuclear cells were isolated from granulocyte colony stimulating factor mobilised peripheral blood. CD34+ cells were selected and separated into adherent and non-adherent cells. Adherent and non-adherent samples were amplified and labelled using two IVT cycles, and gene expression profiling was p...
ORGANISM(S): Homo sapiens 
2008-08-01 | E-MIMR-861 | biostudies-arrayexpress
TranscriptomicsChanges in gene expression of granulocytes during in vivo G-CSF/dexamethasone mobilization.
Treatment of healthy donors with G-CSF and dexamethasone, results in sufficient number of circulating granulocytes to prepare granulocyte concentrates for clinical purposes. Granulocytes obtained this way demonstrate relatively normal functional behavior combined with a prolonged life span. To study...
ORGANISM(S): Homo sapiens 
2010-04-03 | E-GEOD-12841 | biostudies-arrayexpress
ProteomicsThe porcine granulocyte proteome: expression changes in a transgenic pig model for diabetes
As transgenic INSC94Y-pigs develop a stable diabetic phenotype we were able to study the influence of elevated blood glucose levels on primary immune cells in vivo. We investigated the neutrophil proteome and compared data of transgenic animals to a control group. A total of 2371 proteins describing...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2020-06-04 | PXD017274 | Pride
Differential proteomics Innate immune cell Neutrophil granulocyte Diabetes 
TranscriptomicsTranscription profiling of human CD34+ mononuclear cells from individuals with or without Hodgkins lymphoma, cultivated under conditions of granulocyte differentiation
Peripheral blood was the starting material. Mononuclear cells were obtained via apheresis. CD34+ cells were immunomagnetic separated and cultivated under the conditions of granulocyte differentiation.
ORGANISM(S): Homo sapiens 
2008-05-01 | E-MEXP-1283 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse erythroid progenitors (EP) in comparison to granulocyte/monocyte - macrophage progenitors (GMP) from 10 - 16 week old C57/Bl6 - S129Ola
Mouse erythroid progenitors (EP) in comparison to granulocyte/monocyte - macrophage progenitors (GMP) from 10 - 16 week old C57/Bl6 - S129Ola (mixed genetic background) purified by flow cytometry
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-1584 | biostudies-arrayexpress
ProteomicsPhosphoproteomics analysis of normal and mutated granulocyte colony stimulating factor receptors
Granulocyte colony stimulating factor receptor (G-CSFR) plays important role in the production of neutrophils from hematopoietic stem cells. Mutated form of the receptor has been directly associated with two distinct malignant phenotype in patients, e.g. acute myeloid leukemia (AML) and chronic neut...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-14 | PXD009311 | Pride
Phosphoproteomics Silac G-csfr signaling 
ProteomicsGranulocyte-Colony Stimulating Factor reduces cocaine-seeking and downregulates glutamatergic synaptic proteins in medial prefrontal cortex
Abstract Background Psychostimulant use disorder is a major public health issue, and despite the scope of the problem there are currently no FDA approved treatments. There would be tremendous utility in development of a treatment that could help patients both achieve and maintain abstinence. Previou...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-01-28 | PXD019485 | Pride
Cocaine Glutamate Reinstatement Neuroimmune Granulocyte-colony stimulating factor 
TranscriptomicsSPR509: Lung metastasis
Determine gene expression differences between normal, metastatic and non-metastatic mouse lung tissue. Priming of the organ-specific premetastatic sites is thought to be an important yet incompletely understood step during metastasis. In this study, we show that the metastatic tumors we examined ove...
ORGANISM(S): Mus musculus 
2014-11-06 | E-GEOD-62817 | biostudies-arrayexpress
GenomicsGranulocyte-monocyte progenitor (GMP) RNA-seq in wild type and MST1-deficient mice.
Granulocyte-monocyte progenitor (GMP) RNA-seq in wild type and MST1-deficient mice.
PRJNA879324 | ENA
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