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MetabolomicsDeubiquitinase inhibitor compound C6 effect on cellular metabolism
Not available
ORGANISM(S): Mus musculus 
ST000835 | MetabolomicsWorkbench
ProteomicsOn-board Preconcentration Microchip Capillary Electrophoresis Based TMT-PRM-LIVE for High-throughput Selectivity Profiling of Deubiquitinase Inhibitors
On-board Preconcentration Microchip Capillary Electrophoresis Based TMT-PRM-LIVE for High-throughput Selectivity Profiling of Deubiquitinase Inhibitors
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-03-24 | MSV000089122 | MassIVE
TranscriptomicsChIP-chip of Drosophila Polycomb group proteins Asx and Calypso (PR-DUB) in larvae
Analysis of binding profile of the Polycomb group proteins Calypso and Asx (PR-DUB) in Drosophila melanogaster larvae.
ORGANISM(S): Drosophila melanogaster 
2010-05-03 | E-TABM-908 | biostudies-arrayexpress
ProteomicsElectrophile scanning by chemical prote-omics reveals a potent pan-active DUB probe for investigation of deubiquitinase activity in live cells
Deubiquitinases (DUBs) are proteases that hydrolyze isopeptide bonds linking ubiquitin to protein substrates, which can lead to reduced substrate degradation through the ubiquitin proteasome system. Deregulation of DUB activity has been im-plicated in many disease states, including cancer, neurodege...
ORGANISM(S): Homo sapiens (Human) 
2024-01-03 | PXD035417 | Pride
Ubiquitin-activity base probe Deubiquitinase Chemical probe Activity-based probe Electrophilic war-head Ubiquitin Dub Enzyme targeting Myc-deregulated cancer 
ProteomicsDeubiquitinase Vulnerabilities Identified through Activity Based Protein Profiling in Non-Small Cell Lung Cancer
To aid in the prioritization of deubiquitinases (DUBs) as anticancer targets, we developed an approach combining activity-based protein profiling (ABPP) with mass spectrometry in both non-small cell lung cancer (NSCLC) tumor tissues and cell lines along with analysis of available RNA interference an...
ORGANISM(S): Homo sapiens (Human) 
2022-07-05 | PXD028802 | Pride
Human Activity-based protein profiling Deubiquitinase Lung cancer 
UnknownHistone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB.
Not available
S-EPMC3182123 | biostudies-literature
ProteomicsGlobal analysis of cancer cell responses to USP9X inhibition
Mass spectrometry-based 3X-FLAG-Ub-VS deubiquitinase (DUB) competition assay with cell extracts (DUB IP-MS) profiling MCF-7 cells with regard to specificity of WEHI-092, a selective inhibitor for USP9X. Sample key: #1-5 Untreated; #6-10 Ub-VS pre-treatment; #11-15 WEHI-092 treated (50 µM, 60 min).
ORGANISM(S): Homo sapiens (Human) 
2026-04-09 | PXD074545 | Pride
UnknownThe deubiquitinase (DUB) USP13 promotes Mcl-1 stabilisation in cervical cancer.
Not available
S-EPMC7979541 | biostudies-literature
UnknownInterplay of H2A deubiquitinase 2A-DUB/Mysm1 and the p19(ARF)/p53 axis in hematopoiesis, early T-cell development and tissue differentiation.
Not available
S-EPMC4532772 | biostudies-literature
ProteomicsSET7 methylates the deubiquitinase OTUB1 at Lys 122
SET7 methylates the deubiquitinase OTUB1 at Lys 122
ORGANISM(S): Homo Sapiens 
2023-01-16 | PXD040707 |
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