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UnknownAutoantibodies against SUMO1-DHX35 in long-COVID.
Not available
S-EPMC9675633 | biostudies-literature
GenomicsStructural insights into spliceosome fidelity: DHX35-GPATCH1 mediated rejection of aberrant splicing substrates
Structural insights into spliceosome fidelity: DHX35-GPATCH1 mediated rejection of aberrant splicing substrates
PRJNA1213057 | ENA
UnknownThe RNA helicase DHX35 functions as a co-sensor for RIG-I-mediated innate immunity.
Not available
S-EPMC11262647 | biostudies-literature
ProteomicsLC-MS/MS analysis of terminating spliceosomes
In this project, we investigated how the spliceosome bound to an excised intron-lariat is remodeled and how the associated intron-lariat is debranched during the process collectively known as spliceosome termination. We used a native pulldown from a C. elegans strain carrying an endogenous tag on th...
ORGANISM(S): Homo sapiens (Human) Caenorhabditis elegans 
2026-08-19 | PXD081218 | Pride
Human Yju2b Cwf19l1 Leng1 C. elegans Hek293t cells K562 cells Dhx35 Spliceosome Prp19 Dbr1 
UnknownStructural insights into spliceosome fidelity: DHX35-GPATCH1- mediated rejection of aberrant splicing substrates.
Not available
S-EPMC11958768 | biostudies-literature
TranscriptomicsStructural insights into spliceosome fidelity: DHX35-GPATCH1 mediated rejection of aberrant splicing substrates
The spliceosome, a highly dynamic macromolecular assembly, catalyzes the precise removal of introns from pre-mRNAs. Recent studies have provided comprehensive structural insights in the step-wise assembly, catalytic splicing and final disassembly of the spliceosome. However, the molecular details of...
ORGANISM(S): Mus musculus 
2025-03-18 | GSE287473 | GEO
ProteomicsMechanism of spliceosome termination
After removing an intron from pre-mRNA, the spliceosome becomes trapped in a non productive complex bound to the excised intron. The termination of this complex is critical for spliceosome recycling and intron decay, but the underlying mechanism remains unknown. Here, we present cryo-electron micros...
ORGANISM(S): Homo sapiens (Human) 
2026-08-17 | PXD078004 | Pride
Spliceosome 
TranscriptomicsHMJSL C. Neoformans splicing factor knockout RNA-seq
We determined that over 60 spliceosomal proteins are conserved between many fungal species and humans but were lost during the evolution of S. cerevisiae, an intron-poor yeast with unusually rigid splicing signals. We analyzed null mutations in a subset of these factors, most of which had not been i...
ORGANISM(S): Cryptococcus neoformans 
2021-03-13 | GSE168814 | GEO
UnknownSingle-cell proteo-genomic reveals a comprehensive map of centrosome-associated spliceosome components.
Not available
S-EPMC10214398 | biostudies-literature
UnknownStructures of aberrant spliceosome intermediates on their way to disassembly.
Not available
S-EPMC12086092 | biostudies-literature
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