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CWF19L1 promotes T-cell cytotoxicity through the regulation of alternative splicing
Enhancing host anti-tumor immunity is paramount for advancing cancer immunotherapy. Here, we identify CWF19-like cell cycle control factor 1 (CWF19L1) as a promising immunotherapeutic target that functions as a splicing factor to enhance T cell-mediated cytotoxicity. CWF19L1 interacts prominently wi...
ORGANISM(S): Homo sapiens 
2024-08-05 | GSE273485 | GEO
In this project, we investigated how the spliceosome bound to an excised intron-lariat is remodeled and how the associated intron-lariat is debranched during the process collectively known as spliceosome termination. We used a native pulldown from a C. elegans strain carrying an endogenous tag on th...
ORGANISM(S): Homo sapiens (Human) Caenorhabditis elegans 
2026-08-19 | PXD081218 | Pride
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