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ProteomicsLC-MS/MS analysis of terminating spliceosomes
In this project, we investigated how the spliceosome bound to an excised intron-lariat is remodeled and how the associated intron-lariat is debranched during the process collectively known as spliceosome termination. We used a native pulldown from a C. elegans strain carrying an endogenous tag on th...
ORGANISM(S): Homo sapiens (Human) Caenorhabditis elegans 
2026-08-19 | PXD081218 | Pride
Human Yju2b Cwf19l1 Leng1 C. elegans Hek293t cells K562 cells Dhx35 Spliceosome Prp19 Dbr1 
ProteomicsA comprehensive portrait of tissue-, age- and sex-specific DNA modifications in rodents and humans
DNA damage causes genomic instability underlying many diseases, with traditional analytical approaches providing minimal insight into the spectrum of DNA lesions in vivo. Here we used untargeted chromatography-coupled tandem mass spectrometry-based adductomics (LC-MS/MS) to define the landscape of D...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2023-09-12 | PXD045311 | Pride
Adductomics Strp mrm 
ProteomicsMechanism of spliceosome termination
After removing an intron from pre-mRNA, the spliceosome becomes trapped in a non productive complex bound to the excised intron. The termination of this complex is critical for spliceosome recycling and intron decay, but the underlying mechanism remains unknown. Here, we present cryo-electron micros...
ORGANISM(S): Homo sapiens (Human) 
2026-08-17 | PXD078004 | Pride
Spliceosome 
UnknownProteomic Analysis Reveals Sex-Specific Protein Degradation Targets in the Amygdala During Fear Memory Formation.
Not available
S-EPMC8511838 | biostudies-literature
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