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MetabolomicsSupplementation of Bacillus sp. DU-106 reduces hypercholesterolemia and ameliorates gut dysbiosis in high-fat diet rats

Gut microbiota modulation by a probiotic is a novel therapy for hypercholesterolemia mitigation. This study initially investigated the potential hypocholesterolemic effect of Bacillus sp. DU-106 in hypercholesterolemic rats and explored its potential relation with gut microbiota. Sprague-Dawley r...

2021-04-08 | MTBLS1168 | MetaboLights
TranscriptomicsEID1 knochdown by small RNA induces the large-scale conversion of adipose-derived mesenchymal stem cells into hematopoietic stem cells
Comparison of expression profiles in adipose derived MSCs (AD-MSCs) without or with transfection of siR-EID1 and shR-EID1 and cord blood-derived HSCs (CB-HSCs). After MSCs were transfected with sRNA-EID1, they could be converted into HSCs. The goal was to determine possible molecular mechanisms of M...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-42650 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profile in Newcastle disease virus-infected HeLa cells
Three small RNA libraries constructed from uninfected HeLa cells or the cells infected with NDV strain Herts/33 at 6 and 12 hr post inoculation were sequenced using an Illumina platform.Three replicates of each group (Mock, NDV-6h and NDV-12h) were prepared and pooled separately for library construc...
ORGANISM(S): Homo sapiens 
2020-11-08 | E-MTAB-9690 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of hrf1 transformed rice revealed crosstalk between disease resistance and drought tolerance mediated by Harpin
Harpin proteins from Gram-negative plant pathogenic bacteria can activate distinct signaling pathways and cause multiple effects in plants. In this document, we observed the transcriptome profile in transgenic NJH12 and wide type R109 using a customized 57 k rice cDNA microarray and found 225 differ...
ORGANISM(S): Oryza sativa 
2013-12-29 | E-GEOD-36661 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of nasopharyngeal carcinoma cell line HNE2 following TP53 overexpression
Recent studies have revealed that long non-coding RNAs (lncRNAs) participate in all steps of cancer initiation and progression by regulating protein coding genes at the epigenetic, transcriptional and post-transcriptional levels. LncRNAs are in turn regulated by other genes, forming a complex regula...
ORGANISM(S): Homo sapiens 
2015-05-14 | E-GEOD-60379 | biostudies-arrayexpress
ProteomicsTranscriptomic and proteomic analysis reveals a core Atg9 interactome in the regulation of yeast macroautophagy
In Saccharomyces cerevisiae, Atg9 is an important AuTophaGy-related (Atg) protein, plays critical roles in regulating macroautophagy/autophagy, and physically interacts with hundreds of proteins. How Atg9 interacting partners are synergistically orchestrated in autophagy are unclear. Here, we conduc...
ORGANISM(S): Saccharomyces Cerevisiae 
2019-01-19 | PXD012458 |
ProteomicsMulti-omic Profiling of Plasma Identify Biomarkers and Pathogenesis of COVID-19 in Children
Although people of all ages are susceptible to COVID-19, children usually develop less severe disease than adults. Little is known about the pathogenesis of COVID-19 in children. Herein, we conduct the plasma proteomic and metabolomic profiling of a cohort of COVID-19 children patients with mild sym...
ORGANISM(S): Homo Sapiens 
2021-06-28 | PXD026962 |
TranscriptomicsBone marrow gene expression of pediatric acute lymphoblastic leukemia (ALL)
Pediatric acute lymphoblastic leukemia (ALL) contains cytogenetically distinct subtypes that respond differently to cytotoxic drugs. Subtype classification can be also achieved through gene expression profiling. However, how to apply such classifiers to a single patient and correctly diagnose the di...
ORGANISM(S): Homo sapiens 
2009-08-19 | E-GEOD-17703 | biostudies-arrayexpress
ProteomicsAI-facilitated multi-omics reveal TRF-controlled propionylation in determining protein homeostasis
Firstly, we systematically identified rhythmically modified Kpr sites, through time-series propionylomic profiling of fly heads. Wild-type (WT) and per0 flies were entrained under light/dark cycles (LD) and then released into constant darkness (DD), respectively. On the first day of DD, whole heads ...
ORGANISM(S): Drosophila Melanogaster 
2023-03-20 | PXD040987 |
ProteomicsMicroglia and brain organoids
iPSC-derived microglia export cholesterol to neuronal cells in human brain organoids and promote their maturation
ORGANISM(S): Homo Sapiens (human) 
2023-05-19 | PXD042344 | JPOST Repository
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