Sort   by:  
 Page size 
ProteomicsSerum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes
Aims/hypothesis: Biomarkers are needed to accurately predict and monitor type 1 diabetes progression during the substantially heterogeneous presymptomatic period of the disease development. To address this concern, we studied temporal changes in the plasma and serum proteomes of < 5-year-old childre...
ORGANISM(S): Homo Sapiens 
PXD033946 | panorama
ProteomicsHLA-DQ8 Immunopeptidomics, Type 1 Diabetes
In this project we will investigate the peptides present by HLA-DQ8. We will identify linear, spliced and PTM peptides from one cell line.
ORGANISM(S): Homo sapiens (Human) 
2021-07-07 | PXD019466 | Pride
Immunopeptidomics Type 1 diabetes Spliced 
ProteomicsHLA DR1 and DR15 ligands isolated from transgenic mice
Dominant protection from HLA-associated autoimmune disease is conferred by antigen specific regulatory T cells. Susceptibility and protection against human T cell mediated autoimmune diseases, including type I diabetes, multiple sclerosis and Goodpasture’s disease, is associated with particular Huma...
ORGANISM(S): Mus musculus (Mouse) 
2017-05-04 | PXD005935 | Pride
Mouse Dr15 Goodpasture’s disease Dr1 Hla class ii 
ProteomicsHLA-peptidome of human beta cells exposed to interferon-alpha
Interferon (IFN)-α is the earliest cytokine signature observed in individuals at risk for type 1 diabetes (T1D), but its effect on the repertoire of HLA Class I (HLA-I)-bound peptides presented by pancreatic β-cells is unknown. Using immunopeptidomics, we characterized the peptide/HLA-I presentation...
ORGANISM(S): Homo sapiens (Human) 
2025-01-08 | PXD045265 | Pride
Beta cells Hla-peptidome Interferon-alpha Type 1 diabetes 
UnknownSerum proteomics of mother-infant dyads carrying HLA-conferred type 1 diabetes risk.
Not available
S-EPMC11176638 | biostudies-literature
ProteomicsA discovery-based proteomics approach identifies protein disulfide isomerase (PDIA1) as a biomarker of β cell stress in type 1 diabetes
Background: Activation of stress pathways intrinsic to the β cell are thought to both accelerate β cell death and increase β cell immunogenicity in type 1 diabetes (T1D). However, information on the timing and scope of these responses is lacking. Methods: To identify temporal and disease-related c...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD035504 | Pride
Proteomics Β cell stress Protein disulfide isomerase a1 Biomarkers Type 1 diabetes 
ProteomicsHLA-peptidome of human primary islets
Interferon (IFN)-α is the earliest cytokine signature observed in individuals at risk for type 1 diabetes (T1D), but its effect on the repertoire of HLA Class I (HLA-I)-bound peptides presented by pancreatic β-cells is unknown. Using immunopeptidomics, we characterized the peptide/HLA-I presentation...
ORGANISM(S): Homo sapiens (Human) 
2025-01-08 | PXD045211 | Pride
Beta cells Hla-peptidome Islets 
ProteomicsLongitudinal serum proteomics of mother-infant dyads with HLA-conferred type 1 diabetes risk
LC-MS/MS analysis formula was performed for sera from 22 mother-infant dyads with HLA-conferred susceptibility to type 1 diabetes that were weaned to either an extensively hydrolyzed or regular infant milk. The samples included three samples from each mother (at the beginning of third trimester, at ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-27 | PXD046387 | Pride
Human Serum Lc-ms/ms 
ProteomicsAlagebrium chloride therapy acts to preserve beta cell health
Aims/hypothesis AGEs are considered environmental contributors of type 1 diabetes, but the exact role AGEs play early in pathogenesis of the disease, remains unidentified. We aimed to reduce AGEs with the pharmacotherapy alagebrium chloride in MIN6N8 cells and early in life in NOD mice to determine...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-29 | PXD025998 | Pride
Diabetes hla proteomics 
ProteomicsSerum proteomics of mother-infant dyads carrying HLA-conferred type 1 diabetes risk
In-utero and dietary factors make important contributions towards health and development in early childhood. In this respect, serum proteomics of maturing infants can provide insights into studies of childhood diseases, which together with perinatal proteomes could reveal further perspectives. Accor...
ORGANISM(S): Homo Sapiens 
PXD047235 | panorama
Sort   by:  
 Page size