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ProteomicsImpact of CD74 knockdown on the HLA peptidome of the H1 melanoma cell line
The influence of CD74 expression on the HLA peptidome of the H1 melanoma cell line was analyzed by label-free quantitation mass spectrometry of HLA ligand extracts obtained from CD74 siRNA & control siRNA treated cells.
ORGANISM(S): Homo sapiens (Human) 
2018-03-01 | PXD008937 | Pride
Hla peptidome Melanoma Cd74 
ProteomicsHLA B-27 rats peptidome - The HLA-B27 peptidome in vivo in spondyloarthritis-susceptible HLA-B27 transgenic rats and the effect of ERAP1 deletion
HLA-B27 is a class I major histocompatibility (MHC-I) allele that confers susceptibility to the rheumatic disease ankylosing spondylitis (AS) by an unknown mechanism. ERAP1 is an aminopeptidase that trims peptides in the endoplasmic reticulum for binding to MHC-I molecules. ERAP1 shows genetic epist...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-02-13 | PXD005502 | Pride
Transgenic rats Hla-b27 Peptidome Ankylosing spondylitis Human leukocytes antigen 
ProteomicsThe effect of proteasome inhibition on the HLA peptidome
The Major histocompatibility complex (MHC) class I peptidome is thought to be generated mostly through proteasomal degradation of cellular proteins, a notion that is based on the alterations in presentation of selected peptides following proteasome inhibition. We evaluated the effects of proteasome ...
ORGANISM(S): Homo sapiens (Human) 
2018-11-27 | PXD000171 | Pride
Hla peptidome Proteasome inhibitors Dynamic silac 
ProteomicsIdentification of tumor antigens in the HLA peptidome of patient-derived xenograft tumors in mouse
Personalized cancer immunotherapy targeting patient-specific cancer/testis (CTA) antigens and neoantigens may benefit from large-scale tumor HLA peptidome (immunopeptidome) analysis, which aims to accurately identify antigens presented by tumor cells. While significant efforts have been invested in ...
ORGANISM(S): Homo sapiens (Human) 
2020-05-27 | PXD016060 | Pride
Patient derived xenograft Tumor antigen Peptidome Hla 
ProteomicsSubstantial Influence of ERAP2 on the HLA-B*40:02 peptidome. Implications for HLA-B*27-negative ankylosing spondylitis.
HLA-B*40:02 is one of a few Major Histocompatibility Complex class I (MHC-I) molecules associated with ankylosing spondylitis (AS) independently of HLA-B*27. The endoplasmic reticulum aminopeptidase 2 (ERAP2), an enzyme that process MHC-I ligands and preferentially trims N-terminal basic residues, i...
ORGANISM(S): Homo sapiens (Human) 
2019-09-25 | PXD014804 | Pride
Hla-b*40:02 peptidome Hla-b*27 Ankylosing spondylitis Erap2 
ProteomicsRedundancy and Complementarity between ERAP1 and ERAP2 Revealed by their Effects on the Behçet’s Disease-Associated HLA-B*51 Peptidome
The endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 trim peptides to be loaded onto HLA molecules, including the main risk factor for Behçet’s disease HLA-B*51. ERAP1 is also a risk factor among HLA-B*51-positive individuals, whereas no association is known with ERAP2. This study addressed the...
ORGANISM(S): Homo sapiens (Human) 
2019-05-20 | PXD012348 | Pride
Hla-b*51 Erap1 Behçet’s disease Erap2 Peptidome 
ProteomicsRanking the contribution of ankylosing spondylitis-associated ERAP1 polymorphisms to shaping the HLA-B*27 peptidome
The Endoplasmic reticulum aminopeptidase I (ERAP1) trims peptides to their optimal size for binding to Major Histocompatibility Complex class I proteins. The natural polymorphism of this enzyme is associated with ankylosing spondylitis (AS) in epistasis with the major risk factor for this disease, H...
ORGANISM(S): Homo sapiens (Human) 
2018-04-10 | PXD008500 | Pride
Hla Mhc Peptidome Immunopeptidome Human Lc-ms/ms 
ProteomicsIdentification of tumor antigens among the HLA peptidomes of Glioblastoma tumors and plasma
Glioblastoma multiforme (GBM) is the most aggressive brain tumor with poor prognosis to most patients. Immunotherapy of GBM is a potentially beneficial treatment option, whose optimal implementation may depend on familiarity with tumor specific antigens, presented as HLA peptides by the GBM cells. F...
ORGANISM(S): Homo sapiens (Human) 
2019-06-11 | PXD008127 | Pride
Hla peptidome Shla Mhla Glioblastoma Plasma Early detection 
ProteomicsMapping the soluble human leukocyte antigen peptidome of pleural effusions reveals lung and tumor-associated antigens
Soluble HLA (sHLA) molecules released to the plasma, carry their original peptide cargo and provide insight into the protein synthesis and degradation schemes of their source cells and tissues. Other body fluids, such as pleural effusions, may also contain sHLA-peptide complexes, and can potentially...
ORGANISM(S): Homo sapiens (Human) 
2022-05-25 | PXD027766 | Pride
Tumor antigens Immunopeptisome Pleural effusion Cancer/testis antigens Hla peptidome Lung cancer Lc-ms/ms 
UnknownThe effect of proteasome inhibition on the generation of the human leukocyte antigen (HLA) peptidome.
Not available
S-EPMC3708171 | biostudies-literature
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