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ProteomicsMelanoma spliced and linear HLA-I peptides
In this project we have identifed and linear and spliced HLA-I bound peptides to LM-MEl-44, 53 and 33 cell lines in two different condition, treated and not treated with interferone gamma.
ORGANISM(S): Homo sapiens (Human) 
2020-09-25 | PXD014397 | Pride
Spliced peptides Melanoma Hla peptides 
ProteomicsKRAS G12V spliced neoepitope is produced by proteasomes
This dataset contains further evidence that the HLA-A*02:01+ KRAS G12V+ spliced neoepitope we previously identified (Mishto et al., Front. Immunol. 2019) is produced by proteasomes in various experimental conditions
ORGANISM(S): Homo sapiens (Human) 
2022-09-05 | PXD024528 | Pride
Mass spectrometry Epitope discovery Peptide splicing Proteasome Cis-spliced peptides Kras 
ProteomicsEstimating the Contribution of Proteasomal Spliced Peptides to the HLA-I Ligandome
Spliced peptides are short protein fragments spliced together in the proteasome by peptide bond formation. True estimation of the contribution of proteasome-spliced peptides (PSPs) to the global Human Leukocyte Antigen (HLA) ligandome is critical. A recent study suggested that PSPs contribute up to ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-11-13 | MSV000086452 | MassIVE
ProteomicsEstimating the Contribution of Proteasomal Spliced Peptides to the HLA-I Ligandome
Spliced peptides are short protein fragments spliced together in the proteasome by peptide bond formation. True estimation of the contribution of proteasome-spliced peptides (PSPs) to the global Human Leukocyte Antigen (HLA) ligandome is critical. A recent study suggested that PSPs contribute up to ...
ORGANISM(S): Homo sapiens (Human) 
2018-09-03 | PXD010793 | Pride
Lc-msms Immunopeptidomics Proteasomal splicing Hla-i peptides 
ProteomicsIdentification of spliced peptides in pancreatic islets uncovers errors leading to false assignments
Spliced peptides have been identified in the class I major histocompatibility complex (MHC) peptidomes of several tumors and have emerged as novel autoantigens that can stimulate highly specific T cells. A special class of spliced peptides, hybrid insulin peptides (HIPs), bound to histocompatibility...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-02-11 | PXD019819 | Pride
Mhc-i peptidome Crinosomes 
ProteomicsDatabase search engines and target database features impinge upon the identification of post-translationally cis-spliced peptides in HLA class I immunopeptidomes
Unconventional epitopes presented by HLA class I complexes are emerging targets for T cell targeted immunotherapies. Their identification by mass spectrometry required development of novel methods to cope with the large number of theoretical candidates. Methods to identify post-translationally splic...
ORGANISM(S): Homo sapiens (Human) 
2022-04-06 | PXD031709 | Pride
K562 cell line Mass spectrometry Peptide splicing Immunopeptidome Hla-i Cis-spliced peptides 
GenomicsLipofected mRNAs are spliced in Human cells
Lipofected mRNAs are spliced in Human cells
PRJNA1500039 | ENA
TranscriptomicsIdentification of RNAs associated with the Caenorhabditis elegans spliced-leader trans-splicing proteins SNA-2, SNA-3, SNR-2 and SUT-1 proteins by RIP-Seq.
This study aimed to identify RNAs bound to the C. elegans SNA-2, SNA-3, SUT-1 and SNR-2 proteins involved in spliced leader 1 trans-splicing through use of RNA immunoprecipitation sequencing (RIP-Seq). Four IP sample replicates and four control sample replicates were sequenced for each protein.
ORGANISM(S): Caenorhabditis elegans 
2024-04-24 | E-MTAB-13193 | biostudies-arrayexpress
ProteomicsAn AT-hook transcription factor promotes transcription of histone, spliced-leader, and piRNA clusters
In all three domains of life, genes with related functions can be enriched in specific genomic regions, known as the gene clusters. In eukaryotes, histone, piRNA, and rDNA (ribosomal DNA) clusters are among the most notable clusters which play fundamental roles in chromatin formation, genome integri...
ORGANISM(S): Caenorhabditis elegans 
2025-01-29 | PXD055895 | Pride
Histone Spliced-leader At-hook transcription factor Pirna clusters 
TranscriptomicsGenome-wide map of spliced-leader-led trans-splice sites in Oikopleura dioica
Polycistronic mRNAs transcribed from operons are resolved via the trans-splicing of a spliced leader (SL) RNA. The SL is also frequently trans-spliced to monocistronic transcripts. Using a modified cap analysis of gene expression (CAGE) protocol we mapped sites of SL trans-splicing genome-wide in th...
ORGANISM(S): Oikopleura dioica 
2015-01-26 | E-GEOD-50849 | biostudies-arrayexpress
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