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MetabolomicsFunctional targeting of PTTG1 in pericytes restores vascular integrity in diabetic retina

Pericyte loss is an early and critical event in the pathogenesis of diabetic retinopathy (DR), yet the molecular mechanisms underlying pericyte dysfunction remain incompletely understood. Using single-cell RNA sequencing, we generated a retinal cellular overview comprising 18,926 cells from...

2026-03-27 | MTBLS13544 | MetaboLights
ProteomicsProteomics in exploring the endothelial dysfunction mechanism induced by serum exosomes from diabetic retinopathy and diabetic nephropathy patients
In this study, we used human glomerular endothelial cells (HGECs) as cells model, proteomics TMT-based LC-MS/MS was employed to discover the underlying mechanisms of endothelial dysfunction caused by SExos from diabetic retinopathy and nephropathy patients.
ORGANISM(S): Homo Sapiens 
2021-12-29 | PXD030660 |
MetabolomicsFunctional targeting of PTTG1 in pericytes restores vascular integrity in diabetic retina
Pericyte loss is an early and critical event in the pathogenesis of diabetic retinopathy (DR), yet the molecular mechanisms underlying pericyte dysfunction remain incompletely understood. Using single-cell RNA sequencing, we generated a retinal cellular overview comprising 37,982 cells from diabetic...
2026-03-30 | MTBLS14184 | MetaboLights
ProteomicsSalivary biomarkers of diabetic retinopathy, part 1
To characterize human salivary proteome and determine changes in proteins expression in different stages of diabetic retinopathy.
ORGANISM(S): Homo sapiens (Human) 
2016-04-26 | PXD003723 | Pride
Human Type-2diabetes mellitus Saliva Diabetic retinopathy 
TranscriptomicsThe role of insulin resistance in experimental diabetic retinopathy - genetic and molecular aspects
Patients with long-duration diabetes develop cardiovascular complications resulting in highly increased mortality and complications which affect the kidneys, eyes and peripheral nerves associated with high morbidity. Among the diabetic complications, damage in the eye, diabetic retinopathy, is the m...
ORGANISM(S): Rattus norvegicus 
2017-03-31 | E-MTAB-5563 | biostudies-arrayexpress
ProteomicsExtracellular vesicles of human diabetic retinopathy retinal tissue and urine of diabetic retinopathy patients analyzed using mass spectrometry
Diabetic Retinopathy (DR) is a potentially blinding retinal disorder which develops through the pathogenesis of diabetes. Extracellular Vesicles (EVs) provide a novel biomarker for pre-symptomatic disease diagnosis and prognosis. Proteomic analysis was performed on explanted DR retinal tissue, DR r...
ORGANISM(S): Homo sapiens (Human) 
2022-12-31 | PXD034626 | Pride
Lc-ms/ms Exosome Diabetic retinopathy 
ProteomicsPutative tear fluid biomarkers of diabetic retinopathy
Identification of tear fluid biomarkers may offer a non-invasive strategy for detecting diabetic patients with increased risk of developing diabetic retinopathy (DR) or increased disease progression, thus helping both improving diagnostic accuracy and understanding the pathophysiology of the disease...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD033101 | Pride
Human Lc-msms Type 2 diabetes Proliferative diabetic retinopathy Nonproliferative diabetic retinopathy Tear fluid 
ProteomicsIdentification and Validation of microparticle proteins as biomarkers for diabetic retinopathy
Diabetic retinopathy (DR) is a microvascular complication that develops in diabetic individuals. There are currently no methods to detect the onset or progression of DR. Biomarkers can help identify the subset of diabetics who are at high risk of developing DR or those DR patients with a high proba...
ORGANISM(S): Homo sapiens (Human) 
2025-01-17 | PXD036079 | Pride
Diabetic retinopathy Microparticles Serum Biomarkers 
TranscriptomicsSingle cell RNAseq of 12-week old AKIMBA versus WT mouse retina
Single-cell RNA sequencing was performed on retinal tissue from 12-week-old wild-type and Akimba (Ins2AkitaxVEGF+/-) mice, which are known to replicate features of clinical diabetic retinopathy. The aim of this study was to provide deeper insight into the complex network of molecular and cellular ch...
ORGANISM(S): Mus musculus 
2020-05-23 | E-MTAB-9061 | biostudies-arrayexpress
UnknownRisk of diabetic retinopathy at first screen in children at 12 and 13 years of age.
Not available
S-EPMC5434868 | biostudies-literature
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