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ProteomicsNano-liquid chromatography-orbitrap MS/MS-based quantitative proteomics reveals differences between the mechanisms of action of carnosic acid and carnosol in colon cancer cells
A shotgun proteomics study based on stable isotope dimethyl labeling (DML) and nano liquid chromatography-tandem mass spectrometry (nano-LC-MS/MS) has been performed to identify the relative changes in proteins and to gain some light on the specific molecular targets and mechanisms of action of CA a...
ORGANISM(S): Homo sapiens (Human) 
2016-12-23 | PXD004253 | Pride
Carnosol Mass spectrometry Colon cancer Dimethyl labeling Carnosic acid 16 foodomics Ht-29 cells Quantitative proteomics Antiproliferative activity 
ProteomicsSHOTGUN PROTEOMIC ANALYSIS TO STUDY THE DECREASE OF XENOGRAFT TUMOR GROWTH AFTER ROSEMARY EXTRACT TREATMENT
In the present work, the effects of rosemary extract on xenograft tumor growth has been studied and, for the first time, a shotgun proteomic analysis based on nanoliquid chromatography−tandem mass spectrometry (nano-LC−MS/MS) together with stable isotope dimethyl labeling (DML) has been applied to i...
ORGANISM(S): Homo sapiens (Human) 
2017-04-10 | PXD005853 | Pride
Mass spectrometry Colon cancer Dimethyl labeling Xenograft mice Rosemary extract Quantitative proteomics 
ProteomicsComprehensive proteomic study of the antiproliferative activity of a polyphenol-enriched rosemary extract on colon cancer cells using nano-liquid chromatography-Orbitrap MS/MS
A proteomics strategy based on nano-liquid chromatography-tandem mass spectrometry (nano-LC-MS/MS) using an Orbitrap high-resolution mass spectrometer together with stable isotope dimethyl labeling (DML) is applied to quantitatively examine relative changes in the protein fraction of HT-29 human col...
ORGANISM(S): Homo sapiens (Human) 
2016-06-08 | PXD003623 | Pride
Foodomics Mass spectrometry Colon cancer Dimethyl labeling Ht-29 cells Quantitative proteomics Rosemary extract Antiproliferative activity 
ProteomicsProteomic Analysis of Neural Stem Cell to Oligodendrocyte Precursor Cell Differentiation Reveals Phosphorylation-Dependent Dclk1 Processing
The differentiation from neural stem cells (NSCs) to oligodendrocyte precursor cells (OPCs) is only incompletely understood. In the current study, we used the so-called neurosphere assay to study this process. We performed in vitro differentiation from neurospheres (which predominantly consist of NS...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-18 | PXD040652 | Pride
Phosphoproteomics Neural stem cells Dimethyl Tmt Dclk1 Neural development Proximity biotinylation Oligodendrocyte precursor cells Silac Differentiation Isobaric labeling Pura 
ProteomicsTEBP-1 and TEBP-2 are double-stranded telomere binders required for fertility
Telomeres are the ends of linear chromosomes and consist of repetitive double- and single-stranded DNA sequences. Telomeres are bound by dedicated protein complexes, such as shelterin in mammals. In the nematode Caenorhabditis elegans, a comprehensive understanding of the proteins interacting with t...
ORGANISM(S): Caenorhabditis elegans 
2021-03-09 | PXD019241 | Pride
Ip-ms  lc-ms/ms 
ProteomicsLoss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in the zebrafish
Development and function of tissues and organs are powered by the activity of mitochondria. In humans, inherited genetic mutations that lead to progressive mitochondrial pathology often manifest during infancy and can lead to death, reflecting the indispensable nature of mitochondrial function and ...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2018-10-10 | PXD009594 | Pride
Proteomics Danio rerio Mia pathway Dimethyl labeling (dml) Mitochondria Biological 
ProteomicsA Chemical Disruptor of the ClpX Chaperone Complex Attenuates Multiresistant Staphylococcus aureus Virulence
The Staphylococcus aureus ClpXP protease is an important regulator of cell homeostasis and virulence. Here we utilize a high-throughput screen against the ClpXP complex and identify a specific inhibitor of the ClpX chaperone that disrupts its oligomeric state. Synthesis of 34 derivatives revealed th...
ORGANISM(S): Staphylococcus aureus 
2017-09-14 | PXD007259 | Pride
Proteomics Staphylococcus aureus Proteolysis High-throughput screening Antivirulence 
UnknownNano-liquid Chromatography-orbitrap MS-based Quantitative Proteomics Reveals Differences Between the Mechanisms of Action of Carnosic Acid and Carnosol in Colon Cancer Cells.
Not available
S-EPMC5217784 | biostudies-literature
ProteomicsEndothelial Cells from GvsHD Mouse
During inflammation immune cells can induce endothelial activation and angiogenesis by cytokines and other mediators1,2. The inhibition of inflammation-associated angiogenesis ameliorates inflammatory diseases by reducing the recruitment of tissue infiltrating leukocytes3-5. However, there is limite...
ORGANISM(S): Mus musculus (Mouse) 
2017-01-31 | PXD004606 | Pride
Mouse Gvshd Dml Endothelial cells 
ProteomicsSilencing of eIF5B Changes Proteostasis by Providing Negative Feedback on MAPK Signaling
Protein translational machinery is an important component of proteostasis network (PN) that maintains cellular proteostasis and regulates aging and other cellular processes. Ample evidence indicates that inhibition of translation initiation factor activities enhances stress resistance and extends li...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080711 | MassIVE
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