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TranscriptomicsJeB001: Elucidation of the distal convoluted tubule transcriptome identified new candidate players in magnesium balance
The distal convoluted tubule (DCT) plays a key role in the fine-tuning of renal Mg2+ reabsorption. In recent years, hereditary magnesium (Mg2+) transport disorders have helped to identify important players in DCT Mg2+ homeostasis. Here, we report the Mg2+-sensitive transcriptional expression of the ...
ORGANISM(S): Mus musculus 
2013-12-13 | E-GEOD-40208 | biostudies-arrayexpress
ProteomicsSUMOylation proteomic analysis of renal distal convoluted tubule cells
We profiled SUMO1 and SUMO2 modified proteins in distal convoluted tubule (mpkDCT) as a precursor to targeted approaches to assess SUMO function. SUMO levels in cells following heat shock and treatment with deSUMOylation inhibitors were assessed.
ORGANISM(S): Mus musculus (Mouse) 
2021-11-25 | PXD028507 | Pride
Distal convoluted tubule Renal Kidney Sumoylation 
TranscriptomicsIdentification of renal distal convoluted tubules enriched genes
The renal distal convoluted tubule DCT is a short part of the distal nephron with specific functions transporting ions and thereby modifying Na, Ca, Mg, K balance A transcriptomic analysis of the DCT was performed to identify specific gene expression which would implicate those genes in specific DCT...
ORGANISM(S): Mus musculus 
2013-11-19 | E-GEOD-51935 | biostudies-arrayexpress
ProteomicsComparative proteomic analysis of kidney distal convoluted tubule and cortical collecting duct cells following long-term hormonal stimulation
The distal convoluted tubule (DCT) and the cortical collecting ducts (CCD) are portions of renal tubule that are partly responsible for maintaining the systemic concentrations of potassium, sodium, calcium and magnesium. Despite being structurally similar, DCT and CCD cells have different transport ...
ORGANISM(S): Mus musculus (Mouse) 
2017-12-15 | PXD005454 | Pride
Distal convoluted tubule Mouse Hormone Kidney Cortical collecting duct Long-term 
ProteomicsQuantitative Phosphoproteomic Identification of Novel Vasopressin-mediated Signaling Networks in Kidney Distal Convoluted Tubule Cells
The kidney distal convoluted tubule (DCT) plays an important role in body sodium regulation and thus control of blood pressure. The main sodium reabsorption pathways in the DCT are the epithelial sodium channel (ENaC) and the thiazide-sensitive NaCl cotransporter (NCC), the functions of which can be...
ORGANISM(S): Mus musculus (Mouse) 
2015-08-04 | PXD001729 | Pride
Phosphoproteomics Vasopressin Signaling networks Quantitation Kidney distal convoluted tubule cells 
GenomicsEnriched Single-Nucleus RNA-Sequencing Reveals Unique Attributes of Distal Convoluted Tubule Cells
Enriched Single-Nucleus RNA-Sequencing Reveals Unique Attributes of Distal Convoluted Tubule Cells
PRJNA949574 | ENA
TranscriptomicsTranscription profiling of mouse nephron to assess circadian rhythms
Renal excretion of water and major electrolytes exhibits a significant circadian rhythm. This functional periodicity is believed to result, at least in part, from circadian changes in secretion/reabsorption capacities of the distal nephron and collecting ducts. Here, we studied the molecular mechani...
ORGANISM(S): Mus musculus 
2009-10-30 | E-GEOD-17739 | biostudies-arrayexpress
UnknownDistal convoluted tubule.
Not available
S-EPMC5810970 | biostudies-literature
UnknownMechanisms coupling sodium and magnesium reabsorption in the distal convoluted tubule of the kidney.
Not available
S-EPMC7816272 | biostudies-literature
GenomicsThe 3D architecture of gene regulation in the distal convoluted tubule (RNA-Seq)
The 3D architecture of gene regulation in the distal convoluted tubule (RNA-Seq)
PRJNA865304 | ENA
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