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MetabolomicsWe characterize the anti-phage function of a type IV TA system, ShosTA toxin-antitoxin system provides phage defense via DNA damage and repair
Widespread in bacteria and archaea, Toxin-antitoxin (TA) systems have been recently demonstrated to function in phage defense. Here we characterize the anti-phage function of a type IV TA system, ShosTA. Using structural and biochemical approaches, we show that ShosT couples phosphoribosyltransferas...
2025-02-17 | MTBLS11212 | MetaboLights
ProteomicsIdentification of proteins in the interactomes of 4 DNA-repair proteins of Deinococcus radiodurans
Project includes identification of the interacting partners of the four important DNA-repair proteins (DdrA, DdrB, RecA, Ssb) of the extremophile D. radiodurans. The interacting proteins were crosslinked with DSP, immunoprecipitated using antibodies against the four DNA repair proteins, followed by...
ORGANISM(S): Deinococcus radiodurans R1 
2021-05-07 | PXD021822 | Pride
Deinococcus radiodurans dna damage repair 
ProteomicsDNA repair in Mycoplasma gallisepticum
In the current study, we attempted to characterize the DNA repair system of Mycopalsma gallisepticum. We identified members of different DNA repair pathways based on genomic data and publications. We quantified mRNA of respective proteins per cell in a set of adverse conditions and identified most o...
ORGANISM(S): Mycoplasma gallisepticum 
2014-07-30 | PXD000249 | Pride
Dna repair Tof Mycoplasma 
ProteomicsPDHE1α, PARylation, Acetyl-CoA, Acetylation, Histones, DNA damage repair
Chromatin relaxation is a prerequisite step that allows the DNA repair machinery to access double-strand breaks (DSBs), and local histones around the DNA breaks suffer from prompt acetylation changes. However, an intriguing question remains as to where the large demands of acetyl-CoA is precisely pr...
ORGANISM(S): Homo sapiens (Human) 
2023-07-27 | PXD040676 | Pride
Pdhe1α Acetyl-coa Dna damage repair Parylation Histones Acetylation 
UnknownUV-induced histone H2AX phosphorylation and DNA damage related proteins accumulate and persist in nucleotide excision repair-deficient XP-B cells.
Not available
S-EPMC3010519 | biostudies-literature
TranscriptomicsDNA repair and recovery of RNA synthesis following exposure to ultraviolet light are delayed in long genes
The kinetics of DNA repair and RNA synthesis recovery in human cells following UV-irradiation were assessed using nascent RNA Bru-seq and quantitative long PCR. It was found that UV light inhibited transcription elongation and that recovery of RNA synthesis occurred as a wave in the 5’-3’ direction ...
ORGANISM(S): Homo sapiens 
2015-03-03 | E-GEOD-65985 | biostudies-arrayexpress
ProteomicsInhibition of nuclear PTEN tyrosine phosphorylation enhances glioma radiation sensitivity through attenuated DNA repair
Glioblastoma (GBM) is the most lethal brain tumour that occurs in adults and treatment for GBM has been largely unsuccessful. Ionizing radiation (IR) and chemotherapeutic agents are employed as standard of care treatment for GBM patients and both result in DNA damage. Previous data identified phosph...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-08-07 | MSV000081423 | MassIVE
TranscriptomicsExpanding epigenomics to archived FFPE tissues: An evaluation of DNA repair methodologies
A study to evaluate techniques for repairing DNA from formalin-fixed paraffin-embedded (FFPE) tissue samples by direct comparison of FFPE DNA repair methods prior to analysis on genome-wide methylation array to matched fresh frozen (FF) tissues. Formalin-fixed paraffin-embedded tissue from three col...
ORGANISM(S): Homo sapiens 
2014-12-17 | E-GEOD-59038 | biostudies-arrayexpress
TranscriptomicsA Role for Small RNAs in DNA Double-Strand Break Repair
Here we identify a novel class of small RNAs that are ~21-nucleotide in length and are produced from the sequences in the vicinity of DNA double strand break (DSB) sites in Arabidopsis and humans. We named them diRNAs for DSB-induced small RNAs. In Arabidopsis, the biogenesis of diRNAs requires the ...
ORGANISM(S): Arabidopsis thaliana 
2012-03-26 | E-GEOD-36338 | biostudies-arrayexpress
ProteomicsProteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links part 2 of 2: AP-MS DATA (QUBIC)
DNA interstrand crosslinks (ICLs) block replication fork progression by inhibiting DNA strand separation. Repair of ICLs requires sequential incisions, translesion DNA synthesis, and homologous recombination, but the full set of factors involved in these transactions remains unknown. Here we establi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-03-13 | MSV000079577 | MassIVE
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