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ProteomicsDNAJC15 DSP crosslinking interactome in HeLa cells
Mitochondria adapt to cellular stress to ensure cell survival. The stress-regulated mitochondrial peptidase OMA1 orchestrates these adaptive responses, which limit mitochondrial fusion and promote mitochondrial stress signaling and metabolic rewiring. Here, we show that cellular stress adaptation in...
ORGANISM(S): Homo sapiens (Human) 
2026-01-06 | PXD061165 | Pride
Dsp Affinity proteomics Hela Interactome Dnajc15 
ProteomicsWhole cell proteome of DNAJC15 short, uncleavable and wild type overexpression
Mitochondria dynamically adapt to cellular stress to ensure cell survival. The stress-regulated mitochondrial peptidase OMA1 orchestrates these adaptive responses, which limit mitochondrial fusion and promote mitochondrial stress signaling and metabolic rewiring. Here, we show that cellular stress a...
ORGANISM(S): Homo sapiens (Human) 
2026-01-20 | PXD072822 | Pride
Hela Dnajc15 Overexpression 
ProteomicsDNAJC15 endog. interactome DSP-aided in WT and AFG3L2-KO HeLa cells
Mitochondria dynamically adapt to cellular stress to ensure cell survival. The stress-regulated mitochondrial peptidase OMA1 orchestrates these adaptive responses, which limits mitochondrial fusion and promotes mitochondrial stress signaling and metabolic rewiring. Here, we show that cellular stress...
ORGANISM(S): Homo sapiens (Human) 
2025-12-16 | PXD070836 | Pride
Dnacj15 Afg3l2 
GenomicsTranscriptomics DNAJC15 and DNAJC19 knockdown in HeLa cells
Transcriptomics DNAJC15 and DNAJC19 knockdown in HeLa cells
PRJNA1274417 | ENA
ProteomicsTIMM17A and TIMM17B knockdown in DNAJC15 knockout HeLa cells
To understand how OMA1 affects mitochondrial proteostasis and stress responses, we performed a proteomic survey of OMA1-deficient cells for proteolytic substrates. We demonstrate that OMA1 cleaves the mitochondrial chaperone DNAJC15 facilitating its degradation by the mitochondrial m-AAA protease. T...
ORGANISM(S): Homo sapiens (Human) 
2025-12-19 | PXD061131 | Pride
Hela Mitochondria Timm17a Dnajc15 
ProteomicsSILAC-based subcellular fractionation (PM,Golgi,soluble) upon DNAJC15 and DNAJC19 knockdown in HeLa cells
Mitochondria adapt to cellular stress to ensure cell survival. The stress-regulated mitochondrial peptidase OMA1 orchestrates these adaptive responses, which limit mitochondrial fusion and promote mitochondrial stress signaling and metabolic rewiring. Here, we show that cellular stress adaptation in...
ORGANISM(S): Homo sapiens (Human) 
2025-12-16 | PXD061185 | Pride
Dnajc19 Hela Silac Dnajc15 Subcellular 
UnknownChaperoning mitochondrial permeability transition: regulation of transition pore complex by a J-protein, DnaJC15.
Not available
S-EPMC3973195 | biostudies-literature
UnknownETV7-Mediated DNAJC15 Repression Leads to Doxorubicin Resistance in Breast Cancer Cells.
Not available
S-EPMC6077117 | biostudies-literature
TranscriptomicsTranscriptomics DNAJC15 and DNAJC19 knockdown in HeLa cells
To better understand how OMA1 affects mitochondrial proteostasis and stress responses, we performed a proteomic survey of OMA1-deficient cells for proteolytic substrates. We demonstrate that OMA1 cleaves the mitochondrial chaperone DNAJC15 facilitating its degradation by the mitochondrial m-AAA prot...
ORGANISM(S): Homo sapiens 
2025-12-19 | GSE299431 | GEO
GenomicsReleasing the mitochondrial respiration brake MCJ/DnaJC15 enhances CD8 CAR-T cell therapy efficacy
Releasing the mitochondrial respiration brake MCJ/DnaJC15 enhances CD8 CAR-T cell therapy efficacy
PRJNA1096360 | ENA
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