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MetabolomicsG6PD deficiency triggers dopamine loss and the initiation of Parkinson’s Disease pathogenesis
Loss of dopaminergic neurons in Parkinson’s disease (PD) is preceded by loss of synaptic dopamine (DA) and accumulation of proteinaceous aggregates. Linking these deficits is critical to restoring DA signaling in PD. Using murine and human pluripotent stem cell (hPSC) models of PD coupled with human...
2024-10-18 | MTBLS11250 | MetaboLights
ProteomicsVMAT2 dysfunction impairs vesicular dopamine sequestration, driving oxidation and α-synuclein pathology in DJ-1-linked Parkinson’s disease neurons
Parkinson’s disease (PD) is characterized by the selective degeneration of dopaminergic neurons in the substantia nigra, yet its underlying molecular mechanism remains unclear. Excessive dopamine oxidation is a pathological hallmark observed in various forms of PD. Mutations in PD-associated genes, ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-07 | PXD066098 | Pride
Synaptic vesicles Vmat2 Atp Dopamine oxidation Clathrin Dj-1 Parkinson’s disease 
GenomicsDopamine biosynthesis in plants
Dopamine biosynthesis in plants
PRJNA1197496 | ENA
ProteomicsThe involvement of dopamine in the post-translational modification of proteins in sponges
Sponges are the organisms unique for their lack of specialized nerve cells and classical monoamine receptors. Sponges are a highly symbiotic organism, and bacteria make a significant contribution to their biochemical processes. The aim of our project is to investigate the involvement of dopamine in ...
ORGANISM(S): Halisarca dujardinii 
2025-11-06 | PXD066419 | Pride
Dopamine Lc-msms Sponges Proteome 
ProteomicsMitochondrial proteomics investigation of a cellular model of impaired dopamine homeostasis, an early step in Parkinson's disease pathogenesis
Impaired dopamine homeostasis is an early event in the pathogenesis of Parkinson's disease. Generation of intracellular reactive oxygen species consequent to dopamine oxidation leads to mitochondrial dysfunction and eventually cell death. Alterations in the mitochondrial proteome due to dopamine exp...
ORGANISM(S): Homo sapiens (Human) 
2014-04-15 | PXD000838 | Pride
Dopamine  human proteome project  mitochondria  mpp+  parkinson's disease  respiratory chain  shotgun proteomics  mse 
TranscriptomicsDopamine biosynthesis in plants
Dopamine, an essential human neurotransmitter, also plays important roles in plant-microbe interactions and abiotic stress tolerance in plants. Although dopamine biosynthesis is well-characterized in humans, it remains largely unclear in plants. Through metabolite-based genome-wide association studi...
ORGANISM(S): Brachypodium distachyon 
2025-12-27 | GSE284170 | GEO
ProteomicsBeta-synuclein potentiates synaptic vesicle dopamine uptake and rescues dopaminergic neurons from MPTP-induced death in the absence of other synucleins
Previous studies have demonstrated an importance of alpha-synuclein as a modulator of various mechanisms implicated in chemical neurotransmission but information about other two synuclein family members’ involvement in molecular processes taking place in presynaptic terminals is limited. Here we dem...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD027786 | Pride
Dopamine Synapse Mptp toxicity Synuclein Transgenic mice Dopaminergic neurons Parkinson’s disease Vesicles Neurodegenerative disease Neurotransmitter vesicular uptake 
UnknownDopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans.
Not available
S-EPMC3899111 | biostudies-literature
UnknownDopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease.
Not available
S-EPMC6021018 | biostudies-literature
UnknownStudies of Dopamine Oxidation Process by Atmospheric Pressure Glow Discharge Mass Spectrometry.
Not available
S-EPMC10179796 | biostudies-literature
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