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ModelsBest2009 - Homeostatic mechanisms in dopamine synthesis and release
Best2009 - Homeostatic mechanisms in dopamine synthesis and release Encoded non-curated model. Issues: - Initial concentrations for hva, tyrpool, NADPH and NADP are missing - Reaction VMAT requires two substrates to match the formula proposed in the article This model is de...
2015-04-15 | MODEL1502230000 | BioModels
MetabolomicsSETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia
Not available
ORGANISM(S): Homo sapiens 
ST002323 | MetabolomicsWorkbench
ProteomicsThe Parkinson’s disease kinase LRRK2 impairs release sites of vulnerable dopamine axons-APEX2 proteome analysis
We and others previously reported that knock-in mice expressing the pathogenic hyperactive Lrrk2G2019S mutation, exhibit deficits in dopamine release within the striatum. To investigate the underlying molecular mechanisms, we conducted axonal proteome analysis of a subcluster within vulnerable Aldh1...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-19 | PXD065003 | Pride
Lrrk2 Apex2 Proteome analysis 
ModelsYapo2017- cAMP/PKA signalling in D1 dopamine receptor expressing medium-spiny neurons
Yapo2017- cAMP/PKA signalling in D1 dopamine receptor expressing medium-spiny neurons This model is described in the article: Detection of phasic dopamine by D1 and D2 striatal medium spiny neurons. Yapo C, Nair AG, Clement L, Castro LR, Hellgren Kotaleski J, Vincent P. J. Phy...
2017-08-16 | MODEL1701170000 | BioModels
ModelsYapo2017 - A2AR/cAMP/PKA signalling in D2 dopamine receptor expressing medium-spiny neurons
Yapo2017 - A2AR/cAMP/PKA signalling in D2 dopamine receptor expressing medium-spiny neurons This model is described in the article: Detection of phasic dopamine by D1 and D2 striatal medium spiny neurons. Yapo C, Nair AG, Clement L, Castro LR, Hellgren Kotaleski J, Vincent P. ...
2017-08-16 | MODEL1701170001 | BioModels
ProteomicsHeterozygous Hnrnph1 deletion decreases methamphetamine reinforcement, reward, and dopamine release and opposing changes in synaptosomal mitochondrial protein levels
Individual variation in the addiction liability of amphetamines can be explained, in part, by heritable genetic factors. We recently identified Hnrnph1 (heterogeneous nuclear ribonucleoprotein H1) as a quantitative trait gene underlying variance in the locomotor stimulant response to methamphetamine...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-07-29 | MSV000084149 | MassIVE
ProteomicsAxonal and somatodendritic proteomes of dopamine neurons in the mouse brain
Dopamine (DA) neurons modulate neural circuits and behaviors via dopamine release from expansive, long range axonal projections. The elaborate cytoarchitecture of DA neurons is embedded within complex brain tissues, making it difficult to access the DA neuronal proteome using conventional methods. H...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-01 | PXD026229 | Pride
Proteomics Apex2 Dopamine neurons Axon 
ProteomicsThe Parkinson’s disease kinase LRRK2 impairs release sites of vulnerable dopamine axons -striatal synaptosomes phosphoproteomic study
We and others previously reported that knock-in mice expressing the pathogenic hyperactive Lrrk2G2019S mutation, exhibit deficits in dopamine release within the striatum. To investigate the underlying molecular mechanisms, we conducted quantitative phosphoproteomic Liquid Chromatography-Mass Spectro...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-19 | PXD065006 | Pride
Lc-ms Lrrk2 Striatal synaptosomes 
UnknownPlasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter.
Not available
S-EPMC6753151 | biostudies-literature
ProteomicsUnveiling Dopamine and Met-Enkephalin Dynamics: Simultaneous Co-Detection in Rat Striatum
Project description Fast -scan cyclic voltammetry was coupled with carbon microelectrodes for co-detection of dopamine and met-enkephalin at single recording sites in rat striatal slices. The measurements used a specifically designed voltammetric waveform to minimize sensitivity to dopamine, maximiz...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-12-22 | PXD067765 | Pride
Proenkephalin Mass spectrometry Solid-phase extraction Opioid peptide Carbon-fiber microelectrode Fast-scan cyclic voltammetry Mesolimbic pathway 
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