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ProteomicsComparison of Protein Expressions of Drug-Metabolizing Enzymes between Human Liver and the Hepatic Cell Lines HepG2, Hep3B and Huh7 using SWATH and MRM-HR Proteomics
Human hepatic cell lines have been widely used as an in vitro model for the study of drug metabolism and liver toxicity. However, the validity of this model is still a subject of debate because the expressions of various proteins including drug-metabolizing enzymes (DMEs) in the cell lines can diffe...
ORGANISM(S): Homo sapiens (Human) 
2018-04-18 | PXD008190 | Pride
Hep3b Swath Human liver Huh7 Mrm-hr Proteomics Drug-metabolizing enzymes Hepg2 Protein expression 
ProteomicsThe ontogeny and inter-individual variability of drug- metabolizing enzymes and transporters in human liver.
Drug dosing for children is frequently suboptimal when relying on the traditional approach of normalizing doses based on body weight or surface area. Thus, the ontogeny profiling of drug-metabolizing enzymes (DMEs) is important to help develop physiologically-based pharmacokinetic (PBPK) models for ...
ORGANISM(S): Homo sapiens (Human) 
2025-02-05 | PXD060483 | Pride
Ontogeny Human liver Hydrolytic drug-metabolizing enzymes 
GenomicsHepatocyte Nuclear Factors 4a and 1a (Hnf4a and Hnf1a) Regulate Kidney Developmental Expression of Drug-Metabolizing Enzymes and Drug Transporters
The transcriptional regulation of drug-metabolizing enzymes and transporters (here collectively referred to as DMEs) in the developing proximal tubule is not well understood. As in the liver, DME regulation in the PT may be mediated through nuclear receptors which are thought to “sense” deviations f...
ORGANISM(S): Rattus norvegicus 
2014-01-01 | E-GEOD-50815 | biostudies-arrayexpress
TranscriptomicsEffect of Graded Nrf2 Activation on Phase-I and -II Drug Metabolizing Enzymes and Transporters in Mouse Liver
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that induces a battery of cytoprotective genes in response to oxidative/electrophilic stress. Kelch-like ECH associating protein 1 (Keap1) sequesters Nrf2 in the cytosol. The purpose of this study was to investigate the rol...
ORGANISM(S): Mus musculus 
2014-02-18 | E-GEOD-55001 | biostudies-arrayexpress
UnknownINTEDE: interactome of drug-metabolizing enzymes.
Not available
S-EPMC7779056 | biostudies-literature
UnknownMechanisms of promiscuity among drug metabolizing enzymes and drug transporters.
Not available
S-EPMC7138722 | biostudies-literature
GenomicsTranscriptomic Analysis on Lipid Loaded HepaRG Model for Steatosis Reveal the Influence on the Regulation of Drug Metabolizing Enzymes and Transporters
Transcriptomic Analysis on Lipid Loaded HepaRG Model for Steatosis Reveal the Influence on the Regulation of Drug Metabolizing Enzymes and Transporters
PRJNA503838 | ENA
ProteomicsQuantitative Characterization of Clinically Relevant Drug-Metabolizing Enzymes and Transporters in Rat Liver and Intestinal Segments for Applications in PBPK Modeling
Rats are extensively used preclinical models for assessing drug pharmacokinetics (PK) and tissue distribution; however, a successful translation of the rat data requires information on the differences in drug metabolism and transport mechanisms between rats and humans. To partly fill this knowledge ...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-02-05 | PXD039271 | Pride
Pbpk modeling Quantitative proteomics Drug metabolism Total protein approach Digoxin Drug transport Interspecies differences 
ProteomicsMouse liver and kidney proteome with antibiotics treatment
Dysbiosis (alteration of intestinal flora) is associated with various host physiologies, including diseases. The purpose of this study was to clarify the effect of dysbiosis on protein expression levels in mouse liver and kidney by quantitative proteomic analysis, focusing in particular on drug-meta...
ORGANISM(S): Mus Musculus (mouse) 
2018-01-01 | PXD008237 | JPOST Repository
UnknownPharmacogenomics of Drug Metabolizing Enzymes and Transporters: Relevance to Precision Medicine.
Not available
S-EPMC5093856 | biostudies-literature
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