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ProteomicsIdentification of whole-cell dsRNA-binding proteins by phase separation
Interactions between double-stranded RNA (dsRNA) and proteins play an important role in cellular homeostasis by regulating the editing, stability, and splicing of intracellular RNA. The identification of dsRNA-binding proteins (dsRBPs) is key; however, it has long been challenging to purify dsRBPs f...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-10-17 | PXD048971 | Pride
Dsrna-binding domain Dsrna-binding protein capture Armadillo/beta-catenin-like repeats Dsrna-binding proteome Dsrna-binding proteins 
TranscriptomicsTissue Type-Specific Expression of the dsRNA-Binding Protein 76 and Genome-wide Elucidation of its Target mRNAs
RNA-binding proteins accompany all steps in the life of mRNAs and provide dynamic gene regulation functions for rapid adjustment to changing extra- or intracellular conditions. The association of RNA-binding proteins with their targets is regulated through changing sub-cellular distribution, post-tr...
ORGANISM(S): Homo sapiens 
2010-05-04 | E-GEOD-20001 | biostudies-arrayexpress
ProteomicsCellular dsRNA interactome captured by K1 antibody reveals the regulatory map of exogenous RNA sensing
We developed an anti-dsRNA antibody co-immunoprecipitation coupled with quantitative mass spectrometry to comprehensively identify RBPs bound to cellular dsRNAs. To minimize false positives, we conducted a quantitative mass spectrometry analysis under two additional conditions: first, by treating th...
ORGANISM(S): Homo sapiens (Human) 
2025-02-03 | PXD053100 | Pride
Dsrna Dsrbp Interferon response Viral infection Mass spectrometry Rna sensing Crispr-cas9 screening Lc-ms/ms 
TranscriptomicsThe dsRBP and inactive editor, ADR-1, utilizes dsRNA binding to regulate A-to-I RNA editing across the C. elegans transcriptome
Purpose: The purpose of this experiment is to expand the repertoire of C. elegans edited transcripts and identify the roles of ADR-1 as indirect regulator of editing and ADR-2 as the only active deaminase in vivo. Methods: Strand-specific RNA sequencing of wild-type and adr mutant worms, followed by...
ORGANISM(S): Caenorhabditis elegans 
2014-01-20 | E-GEOD-51556 | biostudies-arrayexpress
ProteomicsIdentification of cell membrane proteins involved in dsRNA internalization
Cellular uptake of dsRNA from the environment is a widespread phenomenon among insects. In Drosophila and in honeybees, the injection and the ingestion respectively of dsRNA against a viral sequence is sufficient to hinder virus replication. We wanted to identify cell surface proteins that bind to e...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-04-11 | PXD034508 | Pride
Rna binding Drosophila 
ProteomicsStructural insights into dsRNA processing by Drosophila Dicer-2/Loqs-PD
Small interfering RNAs (siRNAs) are the key components for RNA interference (RNAi), a conserved RNA silencing mechanism in many eukaryotes. In Drosophila, an RNase III enzyme Dicer-2 (Dcr-2), aided by its cofactor Loquacious-PD (Loqs-PD), plays major role in generating 21 base-pair (bp) siRNA duplex...
ORGANISM(S): Drosophila Melanogaster 
2022-04-21 | PXD033365 |
GenomicsCharacterization of dsRNA Binding Proteins through Solubility Analysis Identifies ZNF385A as a dsRNA Homeostasis Regulator
Characterization of dsRNA Binding Proteins through Solubility Analysis Identifies ZNF385A as a dsRNA Homeostasis Regulator
PRJNA1224849 | ENA
GenomicsADAR binding to dsRNA prevents exogenous RNAi from attacking self-produced dsRNA in C. elegans
ADAR binding to dsRNA prevents exogenous RNAi from attacking self-produced dsRNA in C. elegans
PRJNA1001294 | ENA
ProteomicsIntegrative structural analysis of NF90-NF45 heterodimers reveals architectural rearrangements and oligomerisation on binding dsRNA
EDC Crosslinking Mass Spectrometry with quantitation of NF90-NF45 protein complex and NF45-NF90long-dsRNA complex
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053010 | Pride
Crosslinking mass spectrometry Dsrnas Human nf45-nf90 complexes 
ProteomicsDetermination of dsRNA interactome upon Sindbis virus infection in human cells identifies SFPQ as a critical proviral factor
Viruses are obligate intracellular parasites, which depend on the host cellular machineries to replicate their genome and complete their infectious cycle. Long double stranded (ds)RNA is a common viral by-product originating during RNA virus replication, which is universally sensed as a danger signa...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD024554 | Pride
Dsrna Sindbis virus Dsrnaome Sfpq Rbp 
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