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Plasma samples were analyzed using UPLC-MS/MS untargeted metabolomics. The dataset comprised 144 participants. Partial least squares discriminant analysis (PLS-DA) three-dimensional scores plot distinguishing GC patients from non-GC controls. Metabolic profiling and differential comparison identi...

2026-09-29 | MTBLS12684 | MetaboLights
Chromatin accessibility is a hallmark of active regulatory function in the genome and variation of chromatin accessibility across individuals has been shown to contribute to complex traits and disease susceptibility. However, the mechanisms responsible for chromatin variation among different individ...
ORGANISM(S): Mus musculus 
Platelets were isolated from C57BL6/J (C57) mice following established methodology detailed in our prior publication23. In brief, whole blood was collected via the inferior vena cava from C57BL/6J mice (aged 6–8 weeks) under anesthesia induced by 2.5% tribromoethanol (200 mg/kg). Then, an unbiased ...
ORGANISM(S): Mus Musculus 
Obesity is a highly heritable complex disease that results from the interaction of multiple genetic and environmental factors. Formerly obese individuals are susceptible to metabolic disorders later in life, even after lifestyle changes are made to mitigate the obese state. This is reminiscent of th...
ORGANISM(S): Mus musculus 
Autism spectrum disorder (ASD) is a complex set of neurodevelopmental diseases. However, the etiology and pathogenesis of ASD is largely unknown. An integrated proteomics and metabolomics approach was performed on urine sampled from diagnosed ASD children and typical children. All urine protein samp...
ORGANISM(S): Homo Sapiens 
2022-02-11 | PXD031652 |
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