Sort   by:  
 Page size 
MetabolomicsDeubiquitinase inhibitor compound C6 effect on cellular metabolism
Not available
ORGANISM(S): Mus musculus 
ST000835 | MetabolomicsWorkbench
ProteomicsGlobal analysis of cancer cell responses to USP9X inhibition
Mass spectrometry-based 3X-FLAG-Ub-VS deubiquitinase (DUB) competition assay with cell extracts (DUB IP-MS) profiling MCF-7 cells with regard to specificity of WEHI-092, a selective inhibitor for USP9X. Sample key: #1-5 Untreated; #6-10 Ub-VS pre-treatment; #11-15 WEHI-092 treated (50 µM, 60 min).
ORGANISM(S): Homo sapiens (Human) 
2026-04-09 | PXD074545 | Pride
ProteomicsChan et al DUB Inhibitor Disc.
Raw mass spectrometry data files supporting the manuscript "Accelerating Inhibitor Discovery for Deubiquitinating Enzymes"
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-01-04 | MSV000088637 | MassIVE
ProteomicsDeubiquitinase Vulnerabilities Identified through Activity Based Protein Profiling in Non-Small Cell Lung Cancer
To aid in the prioritization of deubiquitinases (DUBs) as anticancer targets, we developed an approach combining activity-based protein profiling (ABPP) with mass spectrometry in both non-small cell lung cancer (NSCLC) tumor tissues and cell lines along with analysis of available RNA interference an...
ORGANISM(S): Homo sapiens (Human) 
2022-07-05 | PXD028802 | Pride
Human Activity-based protein profiling Deubiquitinase Lung cancer 
UnknownDeubiquitinases (DUBs) and DUB inhibitors: a patent review.
Not available
S-EPMC4834700 | biostudies-literature
ProteomicsFirst-in-class DUB Molecular Glues and Inhibitors of Inflammation
Deubiquitylases (DUBs) play a pivotal role in cell signalling and are often regulated by homo- or hetero-interactions within protein complexes. The BRCC36 isopeptidase complex (BRISC) regulates inflammatory signalling by selectively cleaving K63-linked polyubiquitin chains on Type I interferon recep...
ORGANISM(S): Homo sapiens (Human) 
2025-02-06 | PXD044584 | Pride
Inhibitor Molecular glues Hydrogen deuterium exchange Hdx Deubiquitylase 
ProteomicsStructural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor
Inhibition of the mitochondrial deubiquitinating enzyme USP30 is neuroprotective and presents therapeutic opportunities for the treatment of idiopathic Parkinson’s Disease and mitophagy-related disorders. We have integrated structural and quantitative proteomics with biochemical assays to decipher t...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054041 | Pride
Ubiquitin specific protease usp30  cyanopyrrolidine inhibitors Activity-based protein profiling mass spectrometry  enzyme kinetics  hydrogen deuterium exchange-mass spectrometry  molecular docking Mitophagy 
UnknownInteraction of Deubiquitinase 2A-DUB/MYSM1 with DNA Repair and Replication Factors.
Not available
S-EPMC7312997 | biostudies-literature
UnknownThe deubiquitinase (DUB) USP13 promotes Mcl-1 stabilisation in cervical cancer.
Not available
S-EPMC7979541 | biostudies-literature
ProteomicsStructural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor
Inhibition of the mitochondrial deubiquitinating enzyme USP30 is neuroprotective and presents therapeutic opportunities for the treatment of idiopathic Parkinson’s Disease and mitophagy-related disorders. We have integrated structural and quantitative proteomics with biochemical assays to decipher t...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054057 | Pride
Ubiquitin specific protease usp30  cyanopyrrolidine inhibitors Activity-based protein profiling mass spectrometry  enzyme kinetics  hydrogen deuterium exchange-mass spectrometry  molecular docking Mitophagy 
Sort   by:  
 Page size