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ProteomicsIdentification of MRCKA as an integral component of ovarian cancer signaling and a therapeutic target
High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological cancer with few effective targeted therapies. HGSOC tumors exhibit genomic instability with frequent alterations in the protein kinome; however, only a small fraction of the kinome has been therapeutically targeted in HGSOC...
ORGANISM(S): Homo sapiens (Human) 
2020-02-19 | PXD015849 | Pride
Human Mrcka High grade serous ovarian carcinoma Cdc42bpa 
ProteomicsMDR1 Drug Efflux Pump Promotes Acquired and Intrinsic Resistance to Protein Degraders in Cancer Cells
PROTACs (Proteolysis-Targeting Chimeras) represent a revolutionary new class of drugs that selectively degrade proteins of interest from cells. PROTACs targeting oncogenes are avidly being explored for cancer therapies, with several currently in clinical trials. Drug resistance represents a signif...
ORGANISM(S): Homo sapiens (Human) 
2022-10-06 | PXD029233 | Pride
Mdr1 Degrader Cancer Protac Drug resistance Abcb1 
UnknownRac1 selectively binds a specific lamellipodin isoform via a noncanonical helical interface.
Not available
S-EPMC12797038 | biostudies-literature
UnknownAd-SGE-DKK3 Gene Therapy Overcomes Resistance to Immune Checkpoint Blockade in Pleural Mesothelioma.
Not available
S-EPMC12237568 | biostudies-literature
UnknownRac1 Selectively Binds a Specific Lamellipodin Isoform via a Noncanonical Helical Interface.
Not available
S-EPMC12262634 | biostudies-literature
UnknownGenetic variability, combining ability and molecular diversity-based parental line selection for heterosis breeding in field corn (Zea mays L.).
Not available
S-EPMC9262758 | biostudies-literature
UnknownEvaluation of the Predictive Role of Tumor Immune Infiltrate in Patients with HER2-Positive Breast Cancer Treated with Neoadjuvant Anti-HER2 Therapy without Chemotherapy.
Not available
S-EPMC7002194 | biostudies-literature
UnknownCAMKV kinase drives neuroblastoma growth and acts as a novel therapeutic target.
Not available
S-EPMC13643815 | biostudies-literature
ProteomicsKinome Profiling of Gastrointestinal Stromal Tumors Using Multiplexed Inhibitor Beads and Mass Spectrometry Identifies Wee1 as a Candidate Therapeutic Target
Purpose: Management of gastrointestinal stromal tumor (GIST) has been revolutionized by the identification of activating mutations in KIT and PDGFRA and the clinical application of receptor tyrosine kinase (RTK) inhibitors in the advanced disease setting. Stratification of GIST into molecularly defi...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020720 | Pride
Gastrointestinal stromal tumor Pdgfra Kit 
UnknownTumor-infiltrating natural killer cell profiling for therapeutic stratification in patients with resectable non-small cell lung cancer.
Not available
S-EPMC12776338 | biostudies-literature
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