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TranscriptomicsHeLa E2F1 ChIP-chip experiments
These are three biological replicates. HeLa cells were crosslinked on separate days. In each case, a matched total from the same crosslinking was produced in parallel. Amplicons were made from each and hybridized onto ENCODE region tiling arrays. Two color arrays were used; ChIP was red, Total was g...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-4306 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat REF52 cells reveals an E2F1-dependent gene expression program that determines the balance between proliferation and cell death
E2F1 has been shown to induce both proliferation and apoptosis. We now show that PI3K/Akt signaling regulates the balance of these events by specifically blocking expression of genes in the E2F1 apoptotic program but not the proliferative program. Experiment Overall Design: 11 samples total, two rep...
ORGANISM(S): Rattus norvegicus 
2008-06-16 | E-GEOD-9496 | biostudies-arrayexpress
TranscriptomicsExpression data from lenses triply deficient for E2F1, E2F2, and E2F3 transcription factors
The E2F family consists of transcriptional repressors and activators that control cell proliferation. In the classic paradigm of cell cycle regulation, the three activators, E2F1, E2F2 and E2F3, are invariably depicted as the final components of a CDK/Rb signaling cascade that executes the transcrip...
ORGANISM(S): Mus musculus 
2010-06-23 | E-GEOD-16533 | biostudies-arrayexpress
ProteomicsIdentification of E2f1 interactors during early embryonic development in Xenopus tropicalis
In this project, we performed E2f1 immunoprecipitation followed by mass spectrometry analysis to identify its interacting partners during early embryonic development in Xenopus tropicalis.
ORGANISM(S): Xenopus tropicalis 
2025-12-01 | PXD051084 | Pride
Early embryonic development E2f1 Xenopus tropicalis 
TranscriptomicsTranscription profiling of mouse NIH3T3 fibroblasts to investigate E2F1-regulated genes
Identification of E2F1-regulated genes that modulate the transition from quiescence into DNA synthesis, or have roles in apoptosis, signal transduction, membrane biology, and transcription repression.
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-498 | biostudies-arrayexpress
TranscriptomicsA computational genomics approach to identify cis-regulatory modules - a case study using E2F1
We first trained a set of experimentally identified E2F1 targets by a ChIPModules approach, the identified module of E2F1 and AP-2alpha was validated by ChIP-chip assays. We have performed 3 sets of ChIP-chip experiments in MCF-7 for E2F1 and AP-2alpha respectively. The common genes bound by both E2...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-5175 | biostudies-arrayexpress
GenomicsGenome-wide analysis of transcription factor E2F1 mutant proteins reveals that N- and C-terminal protein interaction domains do not participate in targeting E2F1 to the human genome.
Previous studies of E2F family members have suggested that protein-protein interactions may be the mechanism by which E2Fs are recruited to specific genomic regions. We have addressed this hypothesis on a genome-wide scale using ChIP-seq analysis of MCF7 cell lines that express tagged wildtype and m...
ORGANISM(S): Homo sapiens 
2011-04-04 | E-GEOD-28286 | biostudies-arrayexpress
TranscriptomicsE2F1 loss induces spontaneous tumour development in Rb-deficient epidermis
The specific ablation of Rb1 gene in epidermis (RbF/F;K14cre) promotes proliferation and altered differentiation but does not produce spontaneous tumour development. These phenotypic changes are associated with increased expression of E2F members and E2F-dependent transcriptional activity. Here, we ...
ORGANISM(S): Mus musculus 
2012-08-20 | E-GEOD-38048 | biostudies-arrayexpress
TranscriptomicsExpression data from U2OS ER-E2F1 cells after FOXO knockdown and E2F1 activation
Effect of FOXO knockdown on E2F1-mediated transcription U2OS cells stably expressing ER-E2F1 were infected with two different lentiviruses both targeting FOXO1 and FOXO3 or control virus encoding scrambled sequence. Twenty four hours post infection medium was replaced to serum-free DMEM for 24 hour...
ORGANISM(S): Homo sapiens 
2012-07-05 | E-GEOD-39136 | biostudies-arrayexpress
GenomicsHes6 expression is controlled by c-Myc and the AR to promote E2F1 activity and poor outcome in castrate-resistant prostate cancer (E2F1 ChIP-seq)
Hes6 is a transcription co-factor that is associated with stem cell characteristics in neural tissue, but its role in cancer remains uncertain. Here we show that Hes6 is controlled by c-Myc and the AR and can drive castration resistance in xenografts of the androgen-dependent LNCaP prostate cancer c...
ORGANISM(S): Homo sapiens 
2014-04-17 | E-GEOD-36614 | biostudies-arrayexpress
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