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MetabolomicsMulti-omic analysis of vaginal bacteria:host immune and metabolic interactions in early adverse pregnancy outcomes

Objective

To characterise the vaginal microbiota, mucosal metabolome and host immune response in early pregnancy and investigate its relationship with adverse pregnancy outcomes, including ectopic pregnancy, within the context of pregnancies of unknown location (PUL).

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2025-03-28 | MTBLS10098 | MetaboLights
MetabolomicsDiagnostic utility of clinicodemographic, biochemical and metabolite variables to identify viable pregnancies in a symptomatic cohort during early gestation.

Study question: Can a novel machine learning pipeline create predictive models that identify a composite biomarker to differentiate live normally sited pregnancies (LNSP) from non-viable pregnancies in women presenting with pain and/or bleeding in early gestation?

Summary answer: Serum met...

2025-08-14 | MTBLS6219 | MetaboLights
ProteomicsProteome-defined changes in cellular pathways for decidua and trophoblast tissues associated with location and viability of early-stage pregnancy
A label-free proteome analysis comparing changes in protein profiles of decidualized endometria and trophoblasts among women with different pregnancy outcomes, specifically a viable intrauterine pregnancy (IUP), ectopic pregnancy (EP), or early pregnancy loss (EPL), that identify potential biomarker...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-12-16 | MSV000088572 | MassIVE
ProteomicsSystemic changes in early pregnancy in the mare: an integrated proteomic analysis of blood plasma, histotroph and yolk sac fluid at day 14 post-ovulation
Embryo-maternal signaling during the establishment of pregnancy in horses remains one of the biggest mysteries in large animal physiology. Early pregnancy loss represents a major source of economic loss to the breeding industry. This study aimed to investigate the systemic changes associated with ea...
ORGANISM(S): Equus caballus (Horse) 
2025-02-07 | PXD051312 | Pride
Transthyretin Mrp Uteroglobin Secretoglobin Early pregnancy loss Biomarker Ttr 
ProteomicsComprehensive proteomic analysis reveals distinct features and diagnostic biomarker panel for early pregnancy loss in histological subtypes
Early pregnancy loss (EPL) is a common event in human reproduction and is classified into histological subtypes such as hydropic abortion (HA) and hydatidiform moles, including complete hydatidiform moles (CHMs) and partial hydatidiform moles (PHMs). However, accurate diagnosis and improved patient ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053739 | Pride
Proteomic Hydatidiform mole Early pregnancy loss Precious diagnosis Biomarkers 
ProteomicsComprehensive proteomic analysis reveals distinct features and diagnostic biomarker panel for early pregnancy loss in histological subtypes
Early pregnancy loss (EPL) is a common event in human reproduction and is classified into histological subtypes such as hydropic abortion (HA) and hydatidiform moles, including complete hydatidiform moles (CHMs) and partial hydatidiform moles (PHMs). However, accurate diagnosis and improved patient ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055182 | Pride
Proteomic Hydatidiform mole Early pregnancy loss Precious diagnosis Biomarkers 
TranscriptomicsEndometrial expression profiling in women with recurrent early pregnancy loss
Pregnancy loss is the most common complication of human pregnancy. Recurrent early pregnancy loss (REPL) has multiple etiologies, including endometrial dysregulation leading to “suboptimal” implantation. Although the implantation process is tightly regulated in Eutherian (placental) mammals, the ...
ORGANISM(S): Homo sapiens 
2014-12-06 | E-GEOD-63901 | biostudies-arrayexpress
ProteomicsProteomics Study of Molecular Mechanisms Involved in Early Pregnancy Loss
To identify the proteins and molecular signaling pathways that contribute to EPL, we performed proteomics and bioinformatics analysis of the placental villi in women who have undergone EPL and in normal pregnant women.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080693 | MassIVE
ProteomicsProteomics Profiling Reveals Lipid Metabolism Abnormalities During Oogenesis in Unexplained Recurrent Pregnancy Loss
Exploring follicle fluid protein profile, differential expression and signalling pathways in patients with recurrent pregnancy loss.
ORGANISM(S): Homo Sapiens 
2024-04-16 | PXD051475 |
TranscriptomicsDNA methylation profiles in the uterus during early pregnancy
Co-ordinated regulation of endometrial gene expression is essential for successful pregnancy establishment. A non-receptive uterine environment may be a key contributor to pregnancy loss, as the majority of pregnancy losses occur prior to embryo implantation. DNA methylation has been highlighted as...
ORGANISM(S): Bos taurus 
2013-05-03 | E-GEOD-43501 | biostudies-arrayexpress
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