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TranscriptomicsExpression data from Human Umbilical Vein Endothelial Cells (HUVECs) exposed to WT and V30M transthyretin (TTR)
The biological effects of TTR proteins in the vasculature remain unknown. We used microarrays to detail the modulation of gene expression on HUVECs by V30M TTR when compared to cells exposed to WT TTR. HUVECs (passage 7) were cultured in the presence of WT or V30M TTR at 4M-BM-5M for 3 hours. RNA wa...
ORGANISM(S): Homo sapiens 
2013-09-13 | E-GEOD-44856 | biostudies-arrayexpress
UnknownSixty years of transthyretin familial amyloid polyneuropathy (TTR-FAP) in Europe: where are we now? A European network approach to defining the epidemiology and management patterns for TTR-FAP.
Not available
S-EPMC4739317 | biostudies-literature
TranscriptomicsExpression data from Human Umbilical Vein Endothelial Cells (HUVECs) exposed to WT and V30M transthyretin (TTR)
The biological effects of TTR proteins in the vasculature remain unknown. We used microarrays to detail the modulation of gene expression on HUVECs by V30M TTR when compared to cells exposed to WT TTR.
ORGANISM(S): Homo sapiens 
2013-09-13 | GSE44856 | GEO
ProteomicsDevelopment and Validation of a Novel LC-MS/MS Based Proteomics Method for Quantitation of Retinol Binding Protein 4 (RBP4) and Transthyretin (TTR)
Retinol binding protein 4 (RBP4) is the plasma carrier of retinol that complexes with transthyretin (TTR). A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for simultaneous absolute quantitation of serum and plasma RBP4 and TTR is needed to advance the understanding of RBP4 and TT...
ORGANISM(S): Homo Sapiens 
PXD061072 | panorama
ProteomicsIs transthyretin a regulator of Ubc9 SUMOylation?
Ageing and mutations of transthyretin (TTR), the thyroid hormones and retinol transporting protein lead to amyloidosis by destabilizing the structure of TTR. Because protein structure is regulated through posttranslational modifications, we investigated the Small Ubiquitin-like Modifier (SUMO)ylatio...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080754 | MassIVE
UnknownPopulation diversity of the genetically determined TTR expression in human tissues and its implications in TTR amyloidosis.
Not available
S-EPMC5364715 | biostudies-literature
UnknownTTR (Transthyretin) Stabilizers Are Associated With Improved Survival in Patients With TTR Cardiac Amyloidosis.
Not available
S-EPMC5886729 | biostudies-literature
ProteomicsPlasmin activity promotes amyloid deposition in a new transgenic model of human transthyretin amyloidosis.
We have developed a new mouse model of transthyretin (TTR) amyloidosis using transgenic mice expressing the most fibrillogenic variant of TTR (S52P). Following seeding with amyloid fibrils, TTR amyloid is deposited mainly in the heart and tongue. The fibrils contain both full length and truncated ...
ORGANISM(S): Mus musculus (Mouse) 
2021-12-27 | PXD027747 | Pride
Transthyretin Heart Mouse Amyloidosis Tongue 
Genomics
CRISPR gene editior for TTR
PRJNA1069119 | ENA
ProteomicsMass Spectrometry Footprinting Reveals How Kinetic Stabilizers Counteract Transthyretin Dynamics Altered by Pathogenic Mutations_FPOP
Transthyretin (TTR) aggregation causes transthyretin amyloidosis, a severe condition often linked to mutations that destabilize the TTR tetramer, leading to amyloid fibril formation. Small molecules that stabilize the tetramer can prevent this process. While over 300 X-ray structures of TTR exist, t...
ORGANISM(S): Homo sapiens (Human) 
2025-12-13 | PXD071928 | Pride
Transthyretin Fast photochemical oxidation of proteins (fpop) Protein dynamics 37 hydrogen/deuterium exchange mass spectrometry (hdx-ms) 
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