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MetabolomicsAlignment of multiple metabolomics LC-MS datasets from disparate diseases to reveal fever-associated metabolites

Acute febrile illnesses are still a major cause of mortality and morbidity globally, particularly in low to middle income countries. The aim of this study was to determine any possible metabolic commonalities of patients infected with disparate pathogens that cause fever. Three liquid chromatogra...

2023-07-17 | MTBLS4895 | MetaboLights
MetabolomicsA metabolic dependency of EBV can be targeted to hinder B cell transformation

Following infection of B cells, Epstein Barr virus (EBV) engages host pathways that mediate cell proliferation and transformation, contributing to the propensity of the virus to drive immune dysregulation and lymphomagenesis. We found that the EBV protein EBNA2 initiates NAD de novo bios...

2024-04-29 | MTBLS2243 | MetaboLights
GenomicsGenome-wide methylation and expression analysis of two breast cancer cell lines [Methyl-MAPS]
To improve our understanding of the relationships between methylation and expression we profiled mRNA expression and single-base resolution methylation levels for two breast cancer cell lines, MCF7 and T47D. Expression was profiled using RNA-seq. Methylation was assayed using Methyl-MAPS, which use...
ORGANISM(S): Homo sapiens 
2013-06-15 | E-GEOD-45336 | biostudies-arrayexpress
MetabolomicsMetabolic Dynamics of In Vitro CD8+ T Cell Activation

CD8+ T cells detect and kill virally infected or cancerous cells. When activated from their naïve state, T cells undergo a complex transition, including major metabolic reprogramming. Detailed resolution of metabolic dynamics of a wide range of metabolites is needed to advance the field of immuno...

2021-06-02 | MTBLS2145 | MetaboLights
ProteomicsHOW(S) RNAi in Drosophila S2 sells followed by proteomics
Proteomic analysis of S2 cells subjected to RNAi with either HOW(S) specific RNAi duplex or non-specific control
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2026-02-09 | PXD070902 | Pride
Drosophila How(s) 
UnknownmRNA-1273 and Ad26.COV2.S vaccines protect against the B.1.621 variant of SARS-CoV-2.
Not available
S-EPMC9011903 | biostudies-literature
UnknownMS disease activity in RESTORE: a randomized 24-week natalizumab treatment interruption study.
Not available
S-EPMC4011468 | biostudies-literature
ProteomicsROR2 drives right ventricular heart failure via disruption of proteostasis
This study assessed the impact of ROR2 expression on the global proteome using neonatal rat ventricular myocytes (NRVMs) using adenovirus to overexpress ROR2 vs control NRVMs with and without MG132 to block the proteasome to characterize proteasome-mediated clearance.
ORGANISM(S): Rattus norvegicus (Rat) 
2026-04-28 | PXD056556 | Pride
Proteostasis Ror2 Cardiomyocyte 
MetabolomicsUntargeted metabolomics analyses and contaminant chemistry of Dreissenid mussels at the Maumee River Area of Concern in the Great Lakes

Bivalves serve as an ideal ecological indicator; hence, their use by the NOAA Mussel Watch Program to monitor environmental health. This study aimed to expand the baseline knowledge of using metabolic end points in environmental monitoring by investigating the dreissenid mussel metabolome in the ...

2024-06-03 | MTBLS6311 | MetaboLights
ProteomicsStructural proteomics defines a sequential priming mechanism for the progesterone receptor (XL-MS)
The progesterone receptor (PR) is a steroid-responsive nuclear receptor with two isoforms: PR-A and PR-B. Disruption of PR-A:PR-B signaling is associated with breast cancer through interactions with oncogenic co-regulatory proteins (CoRs). However, molecular details of isoform-specific PR-CoR intera...
ORGANISM(S): Homo sapiens (Human) 
2025-04-07 | PXD056360 | Pride
Xl-ms Progesterone receptor Crosslinking 
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