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TranscriptomicsRNAseq analysis of dose/dose rate response after gamma Co-60 exposure on C elegans larvae with focus on reproductive effects
This study investigated cellular events and transcriptomic alterations underlying reproductive defects caused by chronic gamma (γ) radiation in Caenorhabditis elegans (C. elegans). Continuous exposure (0, 1 mGy/h [total dose: 0.048 Gy], 10 mGy/h [total dose: 0.48 Gy] and 100 mGy/h; total dose: 4.8 G...
ORGANISM(S): Caenorhabditis elegans 
2025-11-30 | E-MTAB-15879 | biostudies-arrayexpress
TranscriptomicsUptake and toxic mechanisms following chronic exposure to radium-224 dichloride in Caenorhabditis elegans
the study investigated effects of chronic α irradiation on somatic growth, fertility, germ cell apoptosis, reactive oxygen species (ROS) levels, and the transcriptomic mechanisms using the model organism Caenorhabditis elegans (C. elegans). Furthermore, chronic exposure to 224RaCl2 solutions, with a...
ORGANISM(S): Caenorhabditis elegans 
2026-10-16 | E-MTAB-17706 | biostudies-arrayexpress
MetabolomicsTranscriptomic and metabolomic changes in postharvest sugarbeet roots reveal widespread metabolic changes in storage and identify genes potentially responsible for respiratory sucrose loss
Endogenous metabolism is primarily responsible for losses in sucrose content and processing quality in postharvest sugarbeet roots. The genes responsible for this metabolism and the transcriptional changes that regulate it, however, are largely unknown. To identify genes and metabolic pathways that ...
2024-05-15 | MTBLS1106 | MetaboLights
ProteomicsThe interactome of the Bakers' yeast peroxiredoxin Tsa1 implicates it in the redox regulation of intermediary metabolism, glycolysis and zinc homeostasis
Zinc (Zn) is an essential nutrient supporting a range of critical processes. In the yeast Saccharomyces cerevisiae, Zn deficiency induces a transcriptional response mediated by the Zap1 activator, which controls a regulon of ~80 genes. A subset of these support zinc homeostasis by promoting zinc upt...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-09-07 | PXD060978 | Pride
Tsa1 Zap1 Saccharomyces cerevisiae Peroxiredoxin Label free ip proteomics Zinc Redox regulation 
UnknownThe intronic BRCA1 c.5407-25T>A variant causing partly skipping of exon 23-a likely pathogenic variant with reduced penetrance?
Not available
S-EPMC7382492 | biostudies-literature
TranscriptomicsTranscription profiling of decidua basalis from women with normal pregnancies or preeclampsia and/or fetal growth restriction
The aim of the study was to compare gene expression profiles in decidua basalis from cases with complicated pregnancies to those from healthy pregnant controls. Cases included pregnant women with preeclampsia (PE) and/or fetal growth restriction (FGR). Decidual tissue was obtained by vacuum suction ...
ORGANISM(S): Homo sapiens 
2007-08-31 | E-MEXP-1050 | biostudies-arrayexpress
UnknownPromotion of vesicular zinc efflux by ZIP13 and its implications for spondylocheiro dysplastic Ehlers-Danlos syndrome.
Not available
S-EPMC3529093 | biostudies-literature
TranscriptomicsConcurrent low-dose-rate gamma irradiation and inorganic arsenite in mice: genotoxicity and transcriptional responses in liver and testis in CBA and C57BL/6 mice
Mouse testis and liver samples collected one day post-radiation/As-exposure liver and testis genome-wide transcriptional profiles in male mice of two strains (CBA/CaOlaHsd and C57BL/6NHsd) exposed chronically to a low dose rate (2.5 mGy/h; 1200h, LDR), mid-dose rate (10 mGy/h; 300h, MDR), acutely to...
ORGANISM(S): Mus musculus 
2026-08-28 | E-MTAB-17355 | biostudies-arrayexpress
TranscriptomicsWnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl
Although Bcr-Abl kinase inhibitors have proven effective in the treatment of chronic myeloid leukemia (CML), they generally fail to completely eradicate Bcr-Abl+ leukemia cells. To identify genes whose inhibition sensitizes Bcr-Abl+ leukemias to killing by Bcr-Abl inhibitors, we performed an RNAi-ba...
ORGANISM(S): Homo sapiens 
2010-07-15 | E-GEOD-21499 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization by array of human lymphoma samples
Profiling of DNA copy number alterations by array CGH in 100 sequential samples from 44 patients diagnosed with follicular lymphoma using a inhouse 1 Mb BAC/PAC array CGH
ORGANISM(S): Homo sapiens 
2010-11-03 | E-TABM-930 | biostudies-arrayexpress
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