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ProteomicsLC3A and Aggresomes: A trigger for UPR-activation, mitochondrial dysfunction, and cellular senescence
The protein quality control (PQC) network is crucial for maintaining cellular proteostasis by monitoring protein production, folding, and degradation. Unfolded protein response (UPR) and autophagy are key components of this network along with the compartmentalization of misfolded proteins into inclu...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD043703 | Pride
Autophagy  carcinoma  choroid plexus  endoplasmic reticulum  inclusion bodies  map1lc3a  mitochondria  proteomics  proteostasis  senescence 
ProteomicsCharacterization of ZIC4 role in choroid plexus carcinoma
ZIC4 is a transcription factor related to pathways like NOTCH and Sonic Hedgehog (Shh) pathways which are involved in choroid plexus carcinoma (CPC). The current study describes the effect of ZIC4 gene re-expression on a CPC cell line proteome. We performed SILAC-based proteomics of ZIC4-transfected...
ORGANISM(S): Homo sapiens (Human) 
2024-07-26 | PXD043748 | Pride
Lc-msms Cche-45 Choroid plexus carcinoma Silac Zic4 
ProteomicsProteomics profiling of pediatric choroid plexus tumors
Aggresome is a para nuclear inclusion body that functions as a storage compartment for misfolded proteins. Our previous work revealed the presence of aggresomes in pediatric choroid plexus tumors (CPT). CPTs are rare neoplasms comprised of three pathological subgroups; choroid plexus carcinoma (CPC)...
ORGANISM(S): Homo sapiens (Human) 
2021-02-11 | PXD021076 | Pride
Human Carcinoma Cancer Choroid plexus Tissue Pappiloma Atypical Tumor Pediatric 
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