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TranscriptomicsAttenuation of Global Transcript Changes Induced by Elastase with Symplostatin 5 Cotreatment
Microarray profiling using the Affymetrix GeneChip Human Genome U133 plus 2.0 arrays was performed to comprehensively determine global changes in transcript levels in bronchial epithelial cells following elastase treatment. Elastase caused a significant change in expression (P < 0.05, fold change 1....
ORGANISM(S): Homo sapiens 
2013-01-28 | E-GEOD-41600 | biostudies-arrayexpress
ProteomicsSequential digestion with Trypsin and Elastase in cross-linking/mass spectrometry
Cross-linking/mass spectrometry has become an important approach for studying protein structures and protein-protein interactions. The amino acid composition of some protein regions impedes the detection of cross-linked residues, although it would yield invaluable information for protein modelling. ...
ORGANISM(S): Homo sapiens (Human) Schizosaccharomyces pombe 
2019-03-07 | PXD011459 | Pride
Lc-msms Cross-linking Yeast Human taf4-12 complex 
ProteomicsUnraveling the immunosuppressive role of Elastase B produced by cystic fibrosis isolates of Pseudomonas aeruginosa in an organotypic 3-D lung epithelial cell model
Pseudomonas aeruginosa chronically infects the lungs of people with cystic fibrosis (pwCF), where it produces a broad range of proteases that impact host immunity and inflammation. While some studies suggest these enzymes induce inflammation and may contribute to the excessive inflammatory response ...
ORGANISM(S): Homo sapiens (Human) Pseudomonas aeruginosa PAO1 
2025-10-23 | PXD065321 | Pride
Cystic fibrosis Proteomics Inflammation Elastase b Pseudomonas aeruginosa Bacterial proteases Virulence factors 
TranscriptomicsLung Immune Cells in Wildtype and Cela1-/- Mice 21 Days After Tracheal Porcine Pancreatic Elastase
8-10 week old wildtype and Cela1-/- in C57BL6 background were treated with 2 units of tracheal porcine pancreatic elastase or PBS and on day 21 lungs were collected, flow sorted, and libraries created from lung cells of 3 mice per group using 10X Chromium controller and cellplex lipid hashing oligos...
ORGANISM(S): Mus musculus 
2022-09-23 | E-MTAB-12097 | biostudies-arrayexpress
ProteomicsCELA1 and AAT deficient murine model proteome
Chymotrypsin-like elastase 1 (CELA1) is a serine protease that is neutralized by alpha-1 antitrypsin (AAT) and prevents emphysema in a murine antisense oligonucleotide model of AAT-deficient emphysema. We tested the role of CELA1 in emphysema development in this genetic model of AAT-deficiency follo...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-02-20 | MSV000091330 | MassIVE
TranscriptomicsTranscription profiling of human HLE B-3 cells transfected with hGSTA4-4 expressing vector vs. controls
HLE B-3 cells were transfected with either empty vector or hGSTA4-4 expressing vector to lower intracellular 4-hydroxynonenal levels. hGSTA4-transfected sample has lower HNE levels than pTarget-transfected sample.
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2298 | biostudies-arrayexpress
ProteomicsComparison of the reactivity of hypochlorous acid (HOCl) and hyposelenocyanous acid (HOSeCN) with elastase: role of amino acid modification and structural changes in loss of activity.
Elastase is a serine protease that plays a key role in intracellular and extracellular neutrophil-driven immune responses. There is a synergistic relationship between elastase and myeloperoxidase (MPO), which can boost pathogen killing and limit collateral proteolytic damage to host tissue. However,...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2026-06-22 | PXD075502 | Pride
Inflammation Protease Protein oxidation Selenocyanate Myeloperoxidase 
TranscriptomicsMepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease
For the clinical treatment of chronic obstructive pulmonary disease (COPD), it is important not only to improve the airflow limitation by bronchodilation but also to suppress emphysema by controlling inflammation. In this study, we have screened for compounds that prevent elastase-induced airspace ...
ORGANISM(S): Mus musculus 
2013-11-13 | E-GEOD-50836 | biostudies-arrayexpress
TranscriptomicsLMP1 mediated gene expression changes in transfected CD10+ GC B cells
In this study, we have investigated the effect of LMP1 on gene expression in normal human GC B cells using a non-viral vector based system Experiment Overall Design: Gene expression was compared between LMP1-transfected and control vector-transfected GC B cells from three patients. RNA from the FACS...
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-10821 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HL cell line associated gene expression changes compared with CD10+ GC B cells
Gene expression was compared between four B-cell derived HL cell lines (L428, L1236, L591, KMH2) and GC B cells from three different patients. Experiment Overall Design: Gene expression was compared between four B-cell derived HL cell lines (L428, L1236, L591, KMH2) and GC B cells from three differe...
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-10831 | biostudies-arrayexpress
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