Embryonic lethality

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Unknown (1788)
Genomics (566)
Transcriptomics (433)
Proteomics (49)
Other (21)
Methylation profiling (17)
Metabolomics (4)

Organisms

Mus musculus (427)
Homo sapiens (56)
Caenorhabditis elegans (34)
Aerococcus urinae NBRC 15544 = CCUG 36881 (34)
Allexis (34)
Canis lupus familiaris (34)
Carya cathayensis (34)
Clostridioides difficile 630 (34)
Cyanophora paradoxa (34)
Ensifer adhaerens (34)
Enterococcus faecalis (34)
Danio rerio (20)
Drosophila melanogaster (17)
Arabidopsis thaliana (5)
Rattus norvegicus (3)
Anopheles gambiae (3)
Solanum lycopersicum (3)
Strongylocentrotus purpuratus (2)
Oryzias latipes (2)
Xenopus tropicalis (2)
Sus scrofa (2)
Escherichia coli O157:H7 (1)
artificial sequences (1)
Pseudomonas aeruginosa (1)
Sander lucioperca (1)
Gallus gallus (1)
Macaca mulatta (1)
Mus (1)
Canis lupus familiaris (1)
synthetic construct (1)

Organisms

Mus musculus (308)
Homo sapiens (36)
Caenorhabditis elegans (30)
Danio rerio (14)
Drosophila melanogaster (10)
Solanum lycopersicum (3)
Xenopus tropicalis (2)
Anopheles gambiae (2)
Oryzias latipes (2)
Bos taurus (2)
Sus scrofa (2)
Rattus norvegicus (2)
Anastrepha suspensa (1)
Caenorhabditis briggsae (1)
Sander lucioperca (1)
Mus (1)
Strongylocentrotus purpuratus (1)
Canis lupus familiaris (1)
Bombyx mori (1)
Arabidopsis thaliana (1)

Repository

ENA (471)
geo (405)
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pride (34)
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GNPS (1)
PanoramaPublic (1)

Tissue

Cell culture (6)
Brain (4)
Fibroblast (3)
Liver (3)
Whole body (3)
Early embryonic cell (2)
Egg (2)
Embryonic stem cell (2)
Stem cell (2)
Blood plasma (1)
Embryo (1)
Embryonic fibroblast (1)
Embryonic kidney cell line (1)
Embryonic stem cell line (1)
Endothelial cell (1)
Heart (1)
Lung (1)
Permanent cell line cell (1)
Placenta (1)
Plant cell (1)
Retina (1)

Disease

Congential heart disease (1)
Myeloid neoplasm (1)
Embryonic lethal at day 8.5 to 9.5 (1)
Normal (1)
Hypomyelinating leukodystrophy 7 with or without oligodontia and-or hypogonadotropic hypogonadism (1)
Intellectual disability (1)

Technology Type

Mass Spectrometry (34)
Shotgun proteomics (16)
Affinity purification coupled with mass spectrometry proteomics (8)
Bottom-up proteomics (8)
Data-dependent acquisition (5)
Mass spectrometry (3)
Gel-based experiment (3)
Data-independent acquisition (2)
Illumina HiSeq 2000, ILLUMINA (1)
Chemical cross-linking coupled with mass spectrometry proteomics (1)
SWATH MS (1)
Top-down proteomics (1)

Instrument Platform

Illumina HiSeq 2500 (7)
Illumina NovaSeq 6000 (4)
Illumina HiSeq 4000 (3)
NextSeq 500 (3)
Orbitrap Fusion Lumos (3)
Liquid Chromatography MS - negative - hilic (3)
Orbitrap Eclipse (2)
HiSeq X Five (1)
G2565BA DNA microarray scanner [Agilent] (1)
GenePix 4000B [Axon Instruments] (1)
NextSeq 2000 (1)
HiSeq X Ten (1)
Illumina MiSeq (1)
Illumina HiSeq 2000 (1)
Orbitrap Exploris 480 (1)
Orbitrap Fusion ETD (1)
Liquid Chromatography MS - alternating - hilic (1)
Liquid Chromatography MS - negative - reverse phase (1)
Liquid Chromatography MS - positive - reverse phase (1)
Liquid Chromatography MS - positive - hilic (1)

Publication Date

2025 (64)
2021 (57)
2022 (49)
2024 (46)
2023 (43)
2026 (37)
2013 (36)
2012 (35)
2019 (30)
2015 (28)
2020 (26)
2011 (24)
2014 (23)
2017 (22)
2009 (20)
2018 (19)
2016 (19)
2010 (17)
2007 (9)
2008 (7)
2006 (3)
2005 (2)
2004 (1)
2003 (1)

CHEBI ID

CHEBI:6650 (2)
CHEBI:57865 (1)
CHEBI:58115 (1)
CHEBI:60377 (1)
CHEBI:456215 (1)
CHEBI:68467 (1)
CHEBI:44597 (1)
CHEBI:791 (1)
CHEBI:34159 (1)
CHEBI:144637 (1)
CHEBI:15831 (1)
CHEBI:15534 (1)
CHEBI:37422 (1)
CHEBI:64844 (1)
CHEBI:9481 (1)
CHEBI:15919 (1)
CHEBI:19227 (1)
CHEBI:19702 (1)
CHEBI:110187 (1)
CHEBI:28792 (1)
CHEBI:29019 (1)
CHEBI:17393 (1)
CHEBI:28997 (1)
CHEBI:40410 (1)
CHEBI:37154 (1)
CHEBI:30916 (1)
CHEBI:20129 (1)
CHEBI:36006 (1)
CHEBI:24344 (1)
CHEBI:5417 (1)

Metabolite Name

(2+3)Phosphoglycerate (1)
Fructose-1,6-bisphosphate (1)
N(tele)-methylhistamine (1)
N(2)-methylguanosine (1)
5'-S-methyl-5'-thioadenosine (1)
Indoxyl sulfate (1)
Acetylcysteine (1)
Phthalic acid (1)
Glycerol 1-phosphate (1)
Pyridoxamine 5'-phosphate (1)
All-trans-4-oxoretinol (1)
N(2)-phenylacetyl-L-glutamine (1)
Acamprosate (1)
1-stearoyl-sn-glycero-3-phosphocholine (1)
1-palmitoyl-2-oleoyl-sn-glycero-3-phosphate (1)
15-deoxy-Delta(12,14)-prostaglandin J2 (1)
D-ribofuranose 5-phosphate (1)
Juniperic acid (1)
N(2)-acetylglutamine (1)
4-Hydroxy-D-proline (1)
P-chlorophenylalanine (1)
Prostaglandin D1 (1)
Geranylgeranyl diphosphate (1)
D-mannose 1-phosphate (1)
Thiamine(1+) monophosphate (1)
1-deoxy-D-xylulose 5-phosphate (1)
Oleoyl-CoA (1)
CMP-N-acetyl-beta-neuraminic acid (1)
N-carbamoyl-L-aspartic acid (1)
NADP zwitterion (1)

First Public Date

2025 (62)
2014 (55)
2021 (51)
2022 (49)
2024 (44)
2026 (42)
2023 (37)
2019 (28)
2017 (28)
2020 (23)
2013 (16)
2018 (15)
2015 (14)
2016 (7)

Study type

Transcription profiling by array (96)
RNA-seq of coding RNA (24)
ChIP-seq (11)
Methylation profiling by high throughput sequencing (7)
Cell line - High-throughput sequencing (5)
Unknown experiment type (2)
Animal - High-throughput sequencing (2)
Comparative genomic hybridization by array (2)
RNA-seq of total RNA (2)
RNA-seq of non coding RNA (2)
GRO-seq (1)
Cell line - Two-color microarray (1)
High-throughput sequencing (1)
Bisulfite-seq (1)
MicroRNA profiling by array (1)
Genotyping by high throughput sequencing (1)
RNA-seq of coding RNA from single cells (1)

Release Date

2021 (154)
2020 (121)
2015 (112)
2014 (110)
2025 (107)
2022 (106)
2018 (106)
2012 (106)
2023 (104)
2016 (101)
2017 (96)
2019 (95)
2024 (89)
2013 (87)
2010 (74)
2011 (66)
2009 (62)
2008 (50)
2007 (38)
2006 (38)
2005 (31)
2004 (21)
2003 (15)
2026 (14)
2001 (12)
2002 (11)
2000 (11)
1999 (3)
1998 (3)
1997 (1)

Lab affiliation

Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt; Frankfurt, Germany. (4)
University of Pennsylvania (2)
1 Department of Convergence Medicine, Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Republic of Korea 2 Department of Biomedical Sciences, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea 3 Clinical Proteomics Core Laboratory, Convergence Medicine Research Center, Asan Medical Center, Seoul 05505, Republic of Korea 4 Bio-Medical Institute of Technology, Asan Medical Center, Seoul 05505, Republic of Korea (1)
Babraham Institute Cambridge UK (1)
Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA (1)
Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota (1)
Department of Medical Oncology, University Medical Center Groningen, University of Groningen, the Netherlands, Hanzeplein 1, 9713GZ, Groningen, the Netherlands (1)
Department of Proteomics and Signal Transduction Max Planck Institute of Biochemistry (1)
Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, United Kingdom (1)
Goethe University Frankfurt, University Hospital, Clinic of Neurology, Experimental Neurology, Heinrich- Hoffmann-Str. 7, 60528 Frankfurt am Main, Germany (1)
Harry Perkins Institute of Medical Research and ARC Centre of Excellence in Synthetic Biology, QEII Medical Centre, Nedlands, Western Australia 6009, Australia (1)
Icahn School of Medicine at Mt Sinai (1)
Institut de Génétique et de Biologie Moléculaire et Cellulaire IGBMC, Illkirch, France  Centre National de la Recherche Scientifique, UMR7104, Illkirch, France  Institut National de la Santé et de la Recherche Médicale, U964, Illkirch, France  Université de Strasbourg, Illkirch, France (1)
Institute for Genome Stability in Ageing and Disease, Medical Faculty, University Hospital and University of Cologne, Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany (1)
Institute of Molecular Biology gGmbH(IMB), Mainz, 55128, Germany (1)
Karolinska Institutet, Stockholm, Sweden (1)
Max Planck Institute for Molecular Biomedicine Bioanayltical Mass Spectrometry Röntgenstr. 20 48149 Münster Germany (1)
Max Planck Institute for Molecular Genetics Department of Genome Regulation Ihnestraße 63-73 14195 Berlin, Germany (1)
Molecular Immune and Cell Biology Laboratory of Molecular Immunology Life and Medical Sciences Institute (LIMES), University of Bonn, Carl-Troll-Str.31, 53115 Bonn, Germany (1)
Molecular Immune and Cell Biology Laboratory of Molecular Immunology Life and Medical Sciences Institute (LIMES), University of Bonn, Carl-Troll-Str.31, 53115 Bonn, Germany (lab head) (1)
Penengo Lab, Institute of Molecular Cancer Research, University of Zurich, Switzerland (1)
Professor, Department of Chemistry & Molecular Biology, University of Gothenburg, Box 462, 40530 Göteborg, Sweden (1)
Professor, Division of Inflammation and Proteostasis, Medical Institute of Bioregulation (MIB), Kyushu University Address: 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan Office phone: +81-(0)92-642-4769 Website: https://ikedalab.bioreg.kyushu-u.ac.jp/ Twitter:@IkedaResearch (1)
Proteomics Center, Erasmus MC, Rotterdam, the Netherlands (1)
RNA epigenetics, Institute of Molecular Biology (IMB), Mainz, Germany (1)
TIGEM (1)
Translational Proteomics Laboratory, Institut de recherches cliniques de Montréal (IRCM), Québec, Montréal, Canada. Departement of Biochemistry and Molecular Medicine, Université de Montréal, Québec, Montréal, Canada. (Laboratory Director) (1)
Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35042 Rennes, France (1)
University of Arizona College of Medicine-Tucson (1)
Yale University Department of Molecular Biophysics and Biochemistry (1)

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Maternal lipid mobilization is essential for embryonic development in a key malaria vector

Lipid metabolism is an essential component in reproductive physiology. While lipid mobilization has been implicated in the growth of Plasmodium falciparum malaria parasites in their Anopheles vectors, the role of this process in the reproductive biology of these mosquitoes remains elusive. Here, we ...

2024-11-05 | MTBLS9881 | MetaboLights

Whole embryo RNA-seq of 73 mouse mutant lines and baseline controls from the Mouse Genetics Project (DMDD)

The Deciphering the Mechanisms of Developmental Disorders (DMDD) programme analyses the morphological and molecular phenotypes of embryonic and perinatal lethal mouse mutant lines. Here we show that single whole embryo RNA-seq of 73 mouse mutant lines (>1000 transcriptomes) uncovers transcriptional ...

ORGANISM(S): Mus musculus

2019-10-31 | E-MTAB-7322 | biostudies-arrayexpress

Transcription profiling of homozygous Commd1 null mouse embryos to elucidate the underlying mechanism leading to embryonic lethality

A gene expression study using microarray analysis was performed to elucidate the underlying mechanism leading to embryonic lethality in homozygous Commd1 null (Commd1-/-) mouse embryos. A gene expression profile of 9.5 dpc Commd1-/- embryos were generated and were compared to a gene expression profi...

ORGANISM(S): Mus musculus

2006-09-01 | E-MEXP-832 | biostudies-arrayexpress

DNA-Protein Crosslinks Promote cGAS-STING-driven Premature Aging and Embryonic Lethality

DNA-protein crosslinks (DPCs) are severe DNA lesions that disrupt replication, transcription, and genome stability. However, their role in development and aging remains poorly understood. Here, we show that impaired SPRTN function, a metalloprotease essential for DPC repair during replication and mi...

ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human)

2025-09-30 | PXD051378 | Pride