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ProteomicsEnamel proteome shows that Gigantopithecus was an early diverging pongine
Gigantopithecus blacki was a giant hominid that inhabited Southeast Asia during the Pleistocene. Its evolutionary relationship to other great ape species, and their divergence during the Middle and Late Miocene (16-5.3 Mya), remains disputed. In part, this is due to the absence of cranial and postcr...
ORGANISM(S): Hominidae 
2019-11-12 | PXD013838 | Pride
Enamel Pleistocene Gigantopithecus Lc-msms 
ProteomicsThe TNH2 hominin enamel proteome
Here we analyse two enamel protein extractions from a Middle Pleistocene hominin from Laos, Asia. The proteome is analyzed for potential phylogenetic information and characterized in terms of its molecular damage and in vivo (serine) phosphorylation.
ORGANISM(S): Homo 
2022-04-06 | PXD018721 | Pride
Enamel Lc-ms/ms Phosphorylation Palaeoproteomics 
ProteomicsA Pleistocene hominin enamel proteome from Homo antecessor
Hominin relationships and their dispersal throughout Eurasia during the Early and Middle Pleistocene are highly debated. The relationships between Early and Middle Pleistocene hominins, like Homo antecessor and Homo erectus, and hominin species that dominate the Late Pleistocene fossil record, like ...
ORGANISM(S): Homo 
2020-04-02 | PXD014342 | Pride
Enamel Hominins Phosphorylation Palaeoproteomics Lc-ms/ms 
ProteomicsEarly Pleistocene enamel proteome sequences from Dmanisi resolve Stephanorhinus phylogeny
Ancient DNA (aDNA) sequencing has enabled reconstruction of speciation, migration, and admixture events for extinct taxa. Outside the permafrost, however, irreversible aDNA post-mortem degradation has so far limited aDNA recovery to the past ~0.5 million years (Ma). Contrarily, multiple analyses sug...
ORGANISM(S): Stephanorhinus Equus sp. Bison 
2019-09-11 | PXD011008 | Pride
Enamel Dmanisi Bone Palaeoproteomics Stephanorhinus Dentine Lc-ms/ms 
ProteomicsAutomated high-throughput biological sex identification from archaeological human dental enamel using targeted proteomics
Biological sex is a key information for archaeological and forensic studies, which can be assessed in enamel using proteomics. However, the lack of a standard approach for fast and accurate sex identification limits the reach of proteomics applications. Here, we introduce a targeted proteomics-based...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD049326 | Pride
Forensics Prm Sex Palaeoproteomics Archaeology Enamel 
ProteomicsPig Tooth Pixelation - Tooth enamel forms in an ephemeral protein matrix where changes in protein abundance, composition and post-translational modifications are critical to achieve healthy enamel properties
Tooth enamel forms in an ephemeral protein matrix where changes in protein abundance, composition and post-translational modifications are critical to achieve healthy enamel properties. Amelogenin (AMELX) with its splice variants is the most abundant enamel matrix protein, with only one known phosph...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2019-07-19 | PXD013604 | Pride
Tooth Proteome Pig 
ProteomicsAn early Miocene enamel proteome from an early diverging rhinocerotid
The evolutionary history of Rhinocerotidae has been the subject of significant debate among palaeontologists, with several paradigm shifts within the last quarter century, typically centered around a speculated deep-basal split between Rhinocerotinae and Elasmotheriinae. Here, we recover an endogeno...
ORGANISM(S): Rhinocerotidae 
2025-07-06 | PXD052635 | Pride
Rhinocerotidae Enamel Lc-ms/ms 
ProteomicsNam Lot enamel proteome: part of a multi-proxy approach to exploring Homo sapiens arrival, environments and adaptations in Southeast Asia
Here we analyse two enamel protein extractions from a single Late Pleistocene dental fragment from Nam Lot (Laos). The proteome is analyzed for potential phylogenetic information, from which we concude the specimen represents an individual belonging to the genus Pongo, and characterized in terms of ...
ORGANISM(S): Pongo sp. 
2021-11-30 | PXD027426 | Pride
Palaeproteomics Human evolution Enamel Pleistocene Lc-ms/ms 
ProteomicsPig Enamel, Saliva and Serum Proteome
Molar Hypomineralization is a developmental enamel defect, characterized by demarcated opacities, hypersensitivity, and soft enamel with elevated protein content. Excess protein in enamel, specifically albumin, not only arrests crystal growth during enamel development but also decreases the success ...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-01-26 | PXD030329 | Pride
Enamel Saliva Serum proteomics Pig 
ProteomicsStorage Conditions Differentially Alter the Human Tooth Enamel Proteome
Our findings underscore the importance of both storage methods and standardized protocols in enamel proteomics, as they help avoid bias in protein detection and facilitate comparisons of datasets between studies.
ORGANISM(S): Homo sapiens (Human) 
2025-10-31 | PXD070154 | Pride
Enamel proteome Enamel Proteome Storage condition 
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